Publications equipe 2 depuis 2018

2022

Lagard C, Vodovar D, Chevillard L, Callebert J, Caillé F, Pottier G, Liang H, Risède P, Tournier N, Mégarbane B. Investigation of the Mechanisms of Tramadol- Induced Seizures in Overdose in the Rat. Pharmaceuticals (Basel). 2022 Oct 12;15(10):1254. doi: 10.3390/ph15101254. PMID: 36297366; PMCID: PMC9607071

Mégarbane B, Abe E, Chevillard L. Glimepiride pharmacokinetics in overdose. Clin Toxicol (Phila). 2022 Nov;60(11):1284-1285. doi:10.1080/15563650.2022.2112692. Epub 2022 Aug 18. PMID: 35980254.

Bouzid D, Mullaert J, Ghazali A, Ferré VM, Mentré F, Lemogne C, Ruszniewski P, Faye A, Dinh AT, Mirault T; Université Paris Cité Osce study group. eOSCE stations live versus remote evaluation and scores variability. BMC Med Educ. 2022 Dec 13;22(1):861. doi: 10.1186/s12909-022-03919-1. PMID: 36514011; PMCID: PMC9745699.

Vodovar D, Dufayet L, Mégarbane B. Assessing effectiveness of whole bowel irrigation in poisoning: A laudable effort but still insufficient evidence. Aust Crit Care. 2022 Nov 12:S10367314(22)00204-1. doi: 10.1016/j.aucc.2022.10.003. Epub ahead of print. PMID: 36379838.

Heremans J, Chevillard L, Mannes M, Mangialetto J, Leroy K, White JF, Lamouroux A, Vinken M, Gardiner J, Van Mele B, Van den Brande N, Hoogenboom R, Madder A, Caveliers V, Mégarbane B, Hernot S, Ballet S, Martin C. Impact of doubling peptide length on in vivo hydrogel stability and sustained drug release. J Control Release. 2022 Oct;350:514-524. doi:10.1016/j.jconrel.2022.08.027. Epub 2022 Sep 1. PMID: 35998769.

Dufayet L, Caré W, Laborde-Casterot H, Chouachi L, Langrand J, Vodovar D. Possible impact of the COVID-19 pandemic on the recreational use of nitrous oxide in the Paris area, France. Rev Med Interne. 2022 Jul;43(7):402-405. doi: 10.1016/j.revmed.2022.06.004. Epub 2022 Jun 15. PMID: 35773094; PMCID: PMC9371623.

Jollant F, Blanc-Brisset I, Cellier M, Ambar Akkaoui M, Tran VC, Hamel JF, Piot MA, Nourredine M, Nisse P; French Poison Center Control Research Group; Hawton K, Descatha A, Vodovar D. Temporal trends in calls for suicide attempts to poison control centers in France during the COVID-19 pandemic: a nationwide study. Eur J Epidemiol. 2022 Sep;37(9):901913. doi: 10.1007/s10654-022-00907-z. Epub 2022 Aug 30. PMID: 36040638; PMCID: PMC9425826.

Voiriot G, Oualha M, Pierre A, Salmon-Gandonnière C, Gaudet A, Jouan Y, Kallel H, Radermacher P, Vodovar D, Sarton B, Stiel L, Bréchot N, Préau S, Joffre J; la CRT de la SRLF. Chronic critical illness and post-intensive care syndrome: from pathophysiology to clinical challenges. Ann Intensive Care. 2022 Jul 2;12(1):58. doi: 10.1186/s13613-022-01038-0. PMID: 35779142; PMCID: PMC9250584.

Voicu S, Brudon A, Modestin L, Nitenberg K, Gonde A, Malissin I, Mégarbane B, Reversibility of total airway closure and alveolar consolidation in a COVID-19 patient: A case study. Nurs Crit Care. 2022 Jul;27(4):589-593. doi:10.1111/nicc.12688. Epub 2021 Jul 29. PMID: 34327785; PMCID: PMC8447122.

Dufayet L, Poupon J, Vodovar D, Langrand J. Usefulness of lead isotopes analysis in a pediatric case of chronic lead poisoning. Arch Environ Occup Health. 2023;78(2):98-101. doi: 10.1080/19338244.2022.2063241. Epub 2022 Apr 11. PMID: 35400302.

REMAP-CAP Writing Committee for the REMAP-CAP Investigators; Effect of Antiplatelet Therapy on Survival and Organ Support-Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial. JAMA. 2022 Apr 5;327(13):1247-1259. doi: 10.1001/jama.2022.2910. PMID: 35315874; PMCID: PMC8941448.

Vaucel JA, Enaud N, Paradis C, Bragança C, Courtois A, Lan M, Gil-Jardine C; French PCC Research Group; Enaud R, Labadie M; Investigator list of the French PCC Research Group not listed as main authors; Deguigne M, Roux GL, Descatha A, Azzouz R, Nisse P, Patat AM, Paret N, Blanc-Brisset I, Nardon A, Haro L, Simon N, Delcourt N, Pelissier F, Tournoud C, Puskarczyk E, Langrand J, Laborde- Casterot H, Care W, Vodovar D. Poison control centres and alternative forms of communication: comparison of response rates between text message and telephone follow-up. Clin Toxicol (Phila). 2022 Aug;60(8):947-953. doi: 10.1080/15563650.2022.2051537. Epub 2022 Mar 21. PMID: 35311427.

Pressiat C, Kudela A, De Roux Q, Khoudour N, Alessandri C, Haouache H, Vodovar D, Woerther PL, Hutin A, Ghaleh B, Hulin A, Mongardon N. Population Pharmacokinetics of Amikacin in Patients on Veno-Arterial Extracorporeal Membrane Oxygenation. Pharmaceutics. 2022 Jan 26;14(2):289. doi: 10.3390/pharmaceutics14020289. PMID: 35214022; PMCID: PMC8879580.

Delrue M, Stépanian A, Voicu S, Nassarmadji K, Sène D, Bonnin P, Kevorkian JP, Sellier PO, Molina JM, Neuwirth M, Vodovar D, Mouly S, Mebazaa A, Mégarbane B, Siguret V. No VTE Recurrence After 1-Year Follow-Up of Hospitalized Patients With COVID-19 and a VTE Event: A Prospective Study. Chest. 2022 Jul;162(1):226-229. doi: 10.1016/j.chest.2022.03.043. Epub 2022 Apr 7. PMID: 35398318; PMCID: PMC8986540.

Houzé P, Djebrani Oussedik N, Raimbourg Q, Vodovar D, Poupon J, Labat L. Importance des réseaux sociaux dans l’origine des intoxications : à propos d’un cas d’empoisonnement par la paraphénylènediamine. Ann Biol Clin (Paris). 2022 Mar 1;80(2):175-181. French. doi: 10.1684/abc.2022.1718. PMID: 35766070.

Caré W, Tangre A, Dufayet L, Lekens B, Laborde-Casterot H, Langrand J; French Poison Centers Research Network; Mégarbane B, Vodovar D. Exposure to immediate-release tramadol in children 6 years and under - a nationwide French poison control center study. Clin Toxicol (Phila). 2022 Jun;60(6):750-758. doi:10.1080/15563650.2022.2033257. Epub 2022 Feb 18. PMID: 35179098.

Le Roux C, Destère A, Hervy S, Lloret-Linares C, Reignier J, Caillet P,Jolliet P, Mégarbane B, Boels D. Potential drug-drug interactions when managing status epilepticus patients in intensive care: A cohort study. Br J Clin Pharmacol. 2022 May;88(5):2408-2418. doi: 10.1111/bcp.15179. Epub 2021 Dec 28. PMID: 34907586.

Seifert SA, Buckley N, Chan B, Chan TYK, Cumpston K, Kirschner RI, Megarbane B, Mullins M, Seger D, Thomas S, Vale JA, Wilks M. Clinical Toxicology Review Metrics and Expert Reviewers, 2021. Clin Toxicol (Phila). 2022 Apr;60(4):e1-e3. doi: 10.1080/15563650.2022.2038872. Epub 2022 Feb 17. PMID: 35172657.

Le Dorze M, Martin-Lefèvre L, Santin G, Robert R, Audibert G, Megarbane B, Puybasset L, Dorez D, Veber B, Kerbaul F, Antoine C. Critical pathways for controlled donation after circulatory death in France. Anaesth Crit Care Pain Med. 2022 Apr;41(2):101029. doi: 10.1016/j.accpm.2022.101029. Epub 2022 Feb 1. PMID: 35121185.

Chen CK, Chen YC, Mégarbane B, Yeh YT, Chaou CH, Chang CH, Lin CC. The acute paraquat poisoning mortality (APPM) score to predict the risk of death in paraquat-poisoned patients. Clin Toxicol (Phila). 2022 Apr;60(4):446-450. doi:10.1080/15563650.2021.1979234. Epub 2021 Sep 20. PMID: 34543159.

Dellière S, Dudoignon E, Voicu S, Collet M, Fodil S, Plaud B, Chousterman B, Bretagne S, Azoulay E, Mebazaa A, Dépret F, Mégarbane B, Alanio A. Combination of Mycological Criteria: a Better Surrogate to Identify COVID-19-Associated Pulmonary Aspergillosis Patients and Evaluate Prognosis ? J Clin Microbiol. 2022 mars 16;60(3):e0216921. doi : 10.1128/JCM.02169-21. EPUB 2022 Jan 5.PMID : 3498598.

El Gharbi F, El Bèze N, Jaffal K, Sutterlin L, Mora P, Malissin I, Deye N, Voicu S, Mégarbane B. Does the ICU Requirement Score allow the poisoned patient to be safely managed without admission to the intensive care unit? - a validation cohort study. Clin Toxicol (Phila). 2022 Mar;60(3):298-303. doi: 10.1080/15563650.2021.1961145. Epub 2021 Aug 11.PMID: 34378997.

Bianconi G, Malissin I, Labat L, Khoudour N, Houzé P, Pallet N, Mégarbane B, Declèves X. Marked and prolonged serotonin toxicity in a tramadol-poisoned patient with a pharmacokinetic study. Clin Toxicol (Phila). 2022 Mar;60(3):382-385. doi: 10.1080/15563650.2021.1955912. Epub 2021 Jul 21.PMID: 34287102.

Delrue M, Chevillard L, Stépanian A, Dragoni A, Camoin-Jau L, Voicu S, Malissin I, Deye N, Gainnier M, Siguret V, Mégarbane B. Case series of massive direct oral anticoagulant ingestion-treatment and pharmacokinetics data. Eur J Clin Invest. 2022 Jun;52(6):e13746. doi: 10.1111/eci.13746. Epub 2022 Jan 12. PMID: 35000196.

Vodovar D, Megarbane B. Are sodium nitrite exposures increasing in the United States ? Clin Toxicol (Phila). 2022 Mar;60(3):416-417. doi: 10.1080/15563650.2021.1948560. Epub 2021 Jul 5.PMID: 34219592.

Monsel A, Hauw-Berlemont C, Mebarki M, Heming N, Mayaux J, Nguekap Tchoumba O, Diehl JL, Demoule A, Annane D, Marois C, Demeret S, Weiss E, Voiriot G, Fartoukh M, Constantin JM, Mégarbane B, Plantefève G, Malard-Castagnet S, Burrel S, Rosenzwajg M, Tchitchek N, Boucher-Pillet H, Churlaud G, Cras A, Maheux C, Pezzana C, Diallo MH, Ropers J, Menasché P, Larghero J. Treatment of COVID-19-associated ARDS with mesenchymal stromal cells: a multicenter randomized double-blind trial. APHP STROMA–CoV-2 Collaborative Research Group.Crit Care. 2022 Feb 21;26(1):48. doi: 10.1186/s13054-022-03930-4.PMID: 35189925.

Nguyen P, Chevillard L, Gouda AS, Gourlain H, Labat L, Malissin I, Deye N, Voicu S, Mégarbane B. L-carnitine does not improve valproic acid poisoning management: a cohort study with toxicokinetics and concentration/effect relationships. Ann Intensive Care. 2022 Jan 29;12(1):7. doi: 10.1186/s13613-022-00984-z. PMID: 35092514; PMCID: PMC8800998.

Mégarbane B, Gouda AS. Intravenous Lipid Emulsion for treating Tramadol-Induced Seizures: Surprising but Worth Considering for Future Studies; a Letter to Editor .Arch Acad Emerg Med. 2022 Feb 9;10(1):e14. doi: 10.22037/aaem.v10i1.1541. eCollection 2022.PMID: 35402991.

Bokobza C, Joshi P, Schang AL, Csaba Z, Faivre V, Montané A, Galland A, Benmamar-Badel A, Bosher E, Lebon S, Schwendimann L, Mani S, Dournaud P, Besson V, Fleiss B, Gressens P, Van Steenwinckel. JmiR-146b protects the perinatal brain against microglia-induced hypomyelination. Ann Neurol. 2022 Jan; 91 (1): 48-65. PMID: 34741343; PMCID: PMC9298799

Clergue-Duval V, Coulbault L, Questel F, Cabé N, Laniepce A, Delage C, Boudehent C, Bloch V, Segobin S, Naassila M, Pitel AL, Vorspan F. Alcohol Withdrawal Is an Oxidative Stress Challenge for the Brain: Does It Pave the Way toward Severe Alcohol-Related Cognitive Impairment? Antioxidants (Basel). 2022 Oct 21;11(10):2078. PMID: 36290801; PMCID: PMC9598168.

Delage C, Darnaud L, Etain B, Vignes M, Ly T-K, Frapsauce A, Veyrier M, Delavest M, Marlinge E, Hennion V, Meyrel M, Jacob A, Chouchana M, Smati J, Pataud G, Khoudour N, Fontan J-E, Labat L, Bellivier F, Lloret-linares C, Declèves X, Bloch V. Cytochromes P450 and P-glycoprotein phenotypic assessment to optimize psychotropic pharmacotherapy: a retrospective analysis of four years of practice in psychiatry. J Pers Med. 2022 Nov; PMID: 36579580 PMCID: PMC9693601

Mainoli B, Gonçalves N, Ferreira JJ, Mégarbane B. Potential drug-drug interactions in acute poisonings managed in the intensive care unit: Occurrence, risk factors and relationship to patient severity on admission. Basic Clin Pharmacol Toxicol. 2022 Feb;130(2):337-345. doi: 10.1111/bcpt.13698. Epub 2021 Dec 13.PMID: 34873835.

Gangneux JP et al. Fungal infections in mechanically ventilated patients with COVID-19 during the first wave: the French multicentre MYCOVID study. Lancet Respir Med. 2022 Feb;10(2):180-190. doi: 10.1016/S2213-2600(21)00442-2. Epub 2021 Nov 26. PMID: 34843666.

Trimboli P, Mouly S. Pharmacokinetics and Clinical Implications of Two Non-Tablet Oral Formulations of L-Thyroxine in Patients with Hypothyroidism. J ClinMed. 2022 Jun 16;11(12):3479. doi: 10.3390/jcm11123479. PMID: 35743549; PMCID:PMC9224574.

Mazeraud A et al. Intravenous immunoglobulins in patients with COVID-19-associated moderate-to-severe acute respiratory distress syndrome (ICAR): multicentre, double-blind, placebo-controlled, phase 3 trial. Lancet Respir Med. 2022 Feb;10(2):158-166. doi: 10.1016/S2213-2600(21)00440-9. Epub 2021 Nov 11.PMID: 34774185.

Vodovar D, Mégarbane B. The desperate searching for reliable and convenient criteria of haemodialysis in the lithium-poisoned patient. Br J Clin Pharmacol. 2022 Feb;88(2):877-878. doi: 10.1111/bcp.14950. Epub 2021 Jun 26.PMID: 34174100.

Mégarbane B. The Time Has Come to Understand the Mechanisms by Which Comorbidities Contribute to COVID-19 Severity. J Pers Med. 2022 Jan 18;12(2):123. doi: 10.3390/jpm12020123.PMID: 35207612.

Manry J et al. The risk of COVID-19 death is much greater and age-dependent with type I IFN autoantibodies. Res Sq. 2022 Jan 14:rs.3.rs-1225906. doi: 10.21203/rs.3.rs-1225906/v1. Preprint.PMID: 35043109.

Rouzé A et al. coVAPid study group. Invasive pulmonary aspergillosis among intubated patients with SARS-CoV-2 or influenza pneumonia: a European multicenter comparative cohort study. Crit Care. 2022 Jan 4;26(1):11. doi: 10.1186/s13054-021-03874-1.PMID: 34983611.

Voicu S, Bonnin P, Malissin I, Mohamedi N, M'Rad A, Ekhérian JM, Sutterlin L, Naim G, Lacoste-Palasset T, Deye N, Mégarbane B. haracteristics of deep vein thrombosis in the critically ill COVID-19 patient - an observational cohort study with Doppler ultrasound measurements. Eur Rev Med Pharmacol Sci. 2022 Jan;26(2):686-694. doi: 10.26355/eurrev_202201_27895.PMID: 3511344

Voicu S, Lacoste-Palasset T, Malissin I, Bekhit S, Cauchois E, Dahmani S, Saib M, Grant C, Naim G, M'Rad A, Pepin-Lehaleur A, Ekhérian JM, Deye N, Mégarbane B. Outcome of Critically Ill COVID-19 Patients According to the Setting of Corticosteroid Initiation-A Retrospective Observational Cohort Study..J Pers Med. 2021 Dec 13;11(12):1359. doi: 10.3390/jpm11121359.PMID: 34945831

Dellière S, Dudoignon E, Voicu S, Collet M, Fodil S, Plaud B, Chousterman B, Bretagne S, Azoulay E, Mebazaa A, Dépret F, Mégarbane B, Alanio A. Combination of Mycological Criteria: a Better Surrogate to Identify COVID-19-Associated Pulmonary Aspergillosis Patients and Evaluate Prognosis? J Clin Microbiol. 2022 Mar 16;60(3):e0216921. doi: 10.1128/JCM.02169-21. Epub 2022 Jan 5. PMID:34985983; PMCID: PMC8925884.

El Gharbi F, El Bèze N, Jaffal K, Sutterlin L, Mora P, Malissin I, Deye N, Voicu S, Mégarbane B. Does the ICU Requirement Score allow the poisoned patient to be safely managed without admission to the intensive care unit? – a validation cohort study. Clin Toxicol (Phila). 2022 Mar;60(3):298-303. doi:10.1080/15563650.2021.1961145. Epub 2021 Aug 11. PMID: 34378997.

Monsel A et al. APHP STROMA–CoV-2. Collaborative Research Group. Treatment of COVID-19-associated ARDS with mesenchymal stromal cells: a multicenter randomized double-blind trial. Crit Care. 2022 Feb 21;26(1):48. doi: 10.1186/s13054-022-03930-4. PMID: 35189925;PMCID: PMC8860258.

Mégarbane B, Gouda AS. Intravenous Lipid Emulsion for treating Tramadol-Induced Seizures: Surprising but Worth Considering for Future Studies; a Letter to Editor. Arch Acad Emerg Med. 2022 Feb 9;10(1):e14. doi:10.22037/aaem.v10i1.1541. PMID: 35402991; PMCID: PMC8986489.

2021

Preau S, Vodovar D, Jung B, Lancel S, Zafrani L, Flatres A, Oualha M, Voiriot G, Jouan Y, Joffre J, Uhel F, De Prost N, Silva S, Azabou E, Radermacher P. Correction to: Energetic dysfunction in sepsis: a narrative review. Ann Intensive Care. 2021 Dec 29;11(1):185. doi: 10.1186/s13613-021-00970-x. Erratum for: Ann Intensive Care. 2021 Jul 3;11(1):104. PMID: 34964067; PMCID: PMC8714609.

Caré W, Dufayet L, Piot MA, Crassard I, Manceau P, Niclot P, Batisse A, Vodovar D. Toxicités aiguës et chroniques associées à l’usage et au mésusage du protoxyde d’azote : mise au point [Acute and chronic toxicities associated with the use and misuse of nitrous oxide: An update]. Rev Med Interne. 2022 Mar;43(3):170-177. French. doi: 10.1016/j.revmed.2021.10.008. Epub 2021 Dec 10. PMID: 34903366.

Mainoli B, Gonçalves N, Ferreira JJ, Mégarbane B. Potential drug-drug interactions in acute poisonings managed in the intensive care unit: Occurrence, risk factors and relationship to patient severity on admission. Basic Clin Pharmacol Toxicol. 2022 Feb;130(2):337-345. doi: 10.1111/bcpt.13698. Epub 2021 Dec 13. PMID: 34873835.

Gangneux JP et al. Fungal infections in mechanically ventilated patients with COVID-19 during the first wave: the French multicentre MYCOVID study. Lancet Respir Med. 2022 Feb;10(2):180-190. doi:10.1016/S2213-2600(21)00442-2. Epub 2021 Nov 26. PMID: 34843666; PMCID:PMC8626095.

Vodovar D, Mégarbane B. The desperate searching for reliable and convenient criteria of haemodialysis in the lithium-poisoned patient. Br J Clin Pharmacol. 2022 Feb;88(2):877-878. doi: 10.1111/bcp.14950. Epub 2021 Jun 26. PMID: 34174100.

Manry J et al. The risk of COVID-19 death is much greater and age- dependent with type I IFN autoantibodies. Res Sq [Preprint]. 2022 Jan 14:rs.3.rs-1225906. doi: 10.21203/rs.3.rs-1225906/v1. Update in: Proc Natl Acad Sci U S A. 2022 May 24;119(21):e2200413119. PMID: 35043109; PMCID: PMC8764723.

Massart N et al. COVID ICU Bacteremia Study Group on behalf of the COVID-ICU Investigators. Correction to: Characteristics and prognosis of bloodstream infection in patients with COVID‑19 admitted in the ICU: an ancillary study of the COVID‑ICU study. Ann Intensive Care. 2022 Jan 11;12(1):4. doi: 10.1186/s13613-022-00979-w. Erratum for: Ann Intensive Care. 2021 Dec 24;11(1):183. PMID: 35015163; PMCID: PMC8748185.

Voicu S, Bonnin P, Malissin I, Mohamedi N, M'Rad A, Ekhérian JM, Sutterlin L, Naim G, Lacoste-Palasset T, Deye N, Mégarbane B. Characteristics of deep vein thrombosis in the critically ill COVID-19 patient - an observational cohort study with Doppler ultrasound measurements. Eur Rev Med Pharmacol Sci. 2022 Jan;26(2):686-694. doi: 10.26355/eurrev_202201_27895. PMID: 35113444.

CORIMUNO-19 Collaborative group. Sarilumab in adults hospitalised with moderate-to-severe COVID-19 pneumonia (CORIMUNO-SARI-1): An open-label randomised controlled trial. Lancet Rheumatol. 2022 Jan;4(1):e24-e32. doi: 10.1016/S2665-9913(21)00315-5. Epub 2021 Nov 17. PMID: 34812424; PMCID: PMC8598187.

Vodovar D, Chevillard L, Caillé F, Risède P, Pottier G, Auvity S, Mégarbane B, Tournier N. Mechanisms of respiratory depression induced by the combination of buprenorphine and diazepam in rats. Br J Anaesth. 2022 Mar;128(3):584-595. doi: 10.1016/j.bja.2021.10.029. Epub 2021 Dec 4. PMID: 34872716.

Bouchard J et al. EXTRIP Workgroup. Extracorporeal Treatment for Gabapentin and Pregabalin Poisoning: Systematic Review and Recommendations From the EXTRIP Workgroup. Am J Kidney Dis. 2022 Jan;79(1):88-104. doi: 10.1053/j.ajkd.2021.06.027. Epub 2021 Nov 17. PMID: 34799138.

Massart N et al. COVID ICU Bacteremia Study Group on behalf of the COVID-ICU Investigators. Characteristics and prognosis of bloodstream infection in patients with COVID-19 admitted in the ICU: an ancillary study of the COVID-ICU study. Ann Intensive Care. 2021 Dec 24;11(1):183. doi: 10.1186/s13613-021-00971-w. Erratum in: Ann Intensive Care. 2022 Jan 11;12(1):4. PMID: 34952960; PMCID: PMC8708508.

Voicu S, Lacoste-Palasset T, Malissin I, Bekhit S, Cauchois E, Dahmani S, Saib M, Grant C, Naim G, M'Rad A, Pepin-Lehaleur A, Ekhérian JM, Deye N, Mégarbane B. Outcome of Critically Ill COVID-19 Patients According to the Setting of Corticosteroid Initiation-A Retrospective Observational Cohort Study. J Pers Med. 2021 Dec 13;11(12):1359. doi: 10.3390/jpm11121359. PMID: 34945831; PMCID: PMC8706060.

Schmidt M et al. COVID-ICU Investigators. Predicting 90-day survival of patients with COVID-19: Survival of Severely Ill COVID (SOSIC) scores. Ann Intensive Care. 2021 Dec 11;11(1):170. doi: 10.1186/s13613-021-00956-9. PMID: 34897559; PMCID: PMC8665857.

COVID-ICU group, for the REVA network, COVID-ICU investigators. Benefits and risks of noninvasive oxygenation strategy in COVID-19: a multicenter, prospective cohort study (COVID-ICU) in 137 hospitals. Crit Care. 2021 Dec 8;25(1):421. doi: 10.1186/s13054-021-03784-2. PMID: 34879857; PMCID: PMC8653629.

REMAP-CAP Investigators; ACTIV-4a Investigators; ATTACC Investigators. Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19. N Engl J Med. 2021 Aug 26;385(9):777-789. doi: 10.1056/NEJMoa2103417. Epub 2021 Aug 4. PMID: 34351722; PMCID: PMC8362592.

ATTACC Investigators; ACTIV-4a Investigators; REMAP-CAP Investigators. Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19. N Engl J Med. 2021 Aug 26;385(9):790-802. doi: 10.1056/NEJMoa2105911. Epub 2021 Aug 4. PMID: 34351721; PMCID: PMC8362594.

Grodner C, Bernigaud C, Lapadula S, Beringuer H, Billiet PA, Woerther PL, Billon R, Derhy H, Haye B, Hotz C, Pressiat C, Vodovar D, Rodriguez C, Fabresse N, de Prost N, Hua C, Chosidow O; Henri Mondor Hospital Necrotizing Fasciitis Group. Health products e-sale should be regulated: a case of necrotizing soft- tissue infection of the abdomen linked to self-injection of slimming products purchased on the internet. Int J Dermatol. 2022 Feb;61(2):e52-e54. doi: 10.1111/ijd.15818. Epub 2021 Aug 5. PMID: 34351634.

Galland J, Thoreau B, Delrue M, Neuwirth M, Stepanian A, Chauvin A, Dellal A, Nallet O, Roriz M, Devaux M, London J, Martin-Lecamp G, Froissart A, Arab N, Ferron B, Groff MH, Queyrel V, Lorut C, Regard L, Berthoux E, Bayer G, Comarmond C, Lioger B, Mekinian A, Szwebel TA, Sené T, Amador-Boreiro B, Mangin O, Sellier PO, Mouly S, Kevorkian JP, Siguret V; Lariboisière COVID Group; Vodovar D, Sene D. White blood count, D-dimers, and ferritin levels as predictive factors of pulmonary embolism suspected upon admission in noncritically ill COVID-19 patients: The French multicenter CLOTVID retrospective study. Eur J Haematol. 2021 Aug;107(2):190-201. doi: 10.1111/ejh.13638. Epub 2021 May 24. PMID: 34288162; PMCID: PMC8239942.

Mehrpour O, Saeedi F, Hadianfar A, Mégarbane B, Hoyte C. Prognostic factors of acetaminophen exposure in the United States: An analysis of 39,000 patients. Hum Exp Toxicol. 2021 Dec;40(12_suppl):S814-S825. doi: 10.1177/09603271211061503. Epub 2021 Nov 12. PMID: 34772307.

Mégarbane B, Chevillard L, Khoudour N, Declèves X. Gliclazide disposition in overdose - a case report with pharmacokinetic modeling. Clin Toxicol (Phila). 2022 Apr;60(4):541-542. doi: 10.1080/15563650.2021.1993245. Epub 2021 Oct 26. PMID: 34698608.

Mégarbane B, Bourasset F, Scherrmann JM. Epidemiokinetic Tools to Monitor Lockdown Efficacy and Estimate the Duration Adequate to Control SARS-CoV-2 Spread. J Epidemiol Glob Health. 2021 Dec;11(4):321-325. doi: 10.1007/s44197-021-00007-3. Epub 2021 Sep 20. PMID: 34734383; PMCID: PMC8451385.

Chen CK, Yeh YT, Mégarbane B, Chen YC, Chen KF, Chang CH, Lin CC. A novel flowchart to predict mortality and analyse effectiveness of routinely used pharmacological regimens in paraquat poisoning. Basic Clin Pharmacol Toxicol. 2021 Dec;129(6):496-503. doi: 10.1111/bcpt.13652. Epub 2021 Sep 23. PMID: 34478614.

Chartier M, Desgagné M, Sousbie M, Rumsby C, Chevillard L, Théroux L, Haroune L, Côté J, Longpré JM, Boudreault PL, Marsault É, Sarret P. Pharmacodynamic and pharmacokinetic profiles of a neurotensin receptor type 2 (NTS2) analgesic macrocyclic analog. Biomed Pharmacother. 2021 Sep;141:111861.doi: 10.1016/j.biopha.2021.111861. Epub 2021 Jul 3. PMID: 34229249.

Preau S, Vodovar D, Jung B, Lancel S, Zafrani L, Flatres A, Oualha M, Voiriot G, Jouan Y, Joffre J, Uhel F, De Prost N, Silva S, Azabou E, Radermacher P. Energetic dysfunction in sepsis: a narrative review. Ann Intensive Care. 2021 Jul 3;11(1):104. doi: 10.1186/s13613-021-00893-7. Erratum in: Ann Intensive Care. 2021 Dec 29;11(1):185. PMID: 34216304; PMCID: PMC8254847.

Grémain V, Chevillard L, Saussereau E, Schnell G, Mégarbane B. Massive suicidal ingestion of caffeine: a case report with investigation of the cardiovascular effect/concentration relationships. Clin Toxicol (Phila). 2021 Oct;59(10):937-941. doi: 10.1080/15563650.2021.1891243. Epub 2021 Mar 10. PMID: 33688777.

Vodovar D, Tournoud C, Boltz P, Paradis C, Puskarczyk E. Severe intentional sodium nitrite poisoning is also being seen in France. Clin Toxicol (Phila). 2022 Feb;60(2):272-274. doi: 10.1080/15563650.2021.1919695. Epub 2021 May 14. PMID: 33988068.

Thoreau B, Galland J, Delrue M, Neuwirth M, Stepanian A, Chauvin A, Dellal A, Nallet O, Roriz M, Devaux M, London J, Martin-Lecamp G, Froissart A, Arab N, Ferron B, Groff MH, Queyrel V, Lorut C, Regard L, Berthoux E, Bayer G, Comarmond C, Lioger B, Mekinian A, Szwebel TA, Sené T, Amador-Borrero B, Mangin O, Sellier PO, Siguret V, Mouly S, Kevorkian JP, Lariboisière Covid Group, Vodovar D, Sene D. D-Dimer Level and Neutrophils Count as Predictive and Prognostic Factors of Pulmonary Embolism in Severe Non-ICU COVID-19 Patients. Viruses. 2021 Apr 26;13(5):758. doi: 10.3390/v13050758. PMID: 33926038; PMCID: PMC8146364.

Dufayet L, Care W, Deheul S, Laborde-Casterot H, Nisse P; French PCC Research Group; Langrand J, Vodovar D. Increase in pregabalin recreational use in adolescents in France. Clin Toxicol (Phila). 2021 Nov;59(11):1027-1030. doi: 10.1080/15563650.2021.1892719. Epub 2021 Mar 18. PMID: 33733968.

REMAP-CAP Investigators; Gordon AC, Mouncey PR, Al-Beidh F, Rowan KM, Nichol AD, Arabi YM, Annane D, Beane A, van Bentum-Puijk W, Berry LR, Bhimani Z, Bonten MJM, Bradbury CA, Brunkhorst FM, Buzgau A, Cheng AC, Detry MA, Duffy EJ, Estcourt LJ, Fitzgerald M, Goossens H, Haniffa R, Higgins AM, Hills TE, Horvat CM, Lamontagne F, Lawler PR, Leavis HL, Linstrum KM, Litton E, Lorenzi E, Marshall JC, Mayr FB, McAuley DF, McGlothlin A, McGuinness SP, McVerry BJ, Montgomery SK, Morpeth SC, Murthy S, Orr K, Parke RL, Parker JC, Patanwala AE, Pettilä V, Rademaker E, Santos MS, Saunders CT, Seymour CW, Shankar-Hari M, Sligl WI, Turgeon AF, Turner AM, van de Veerdonk FL, Zarychanski R, Green C, Lewis RJ, Angus DC, McArthur CJ, Berry S, Webb SA, Derde LPG. Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19. N Engl J Med. 2021 Apr 22;384(16):1491-1502. doi: 10.1056/NEJMoa2100433. Epub 2021 Feb 25. PMID: 33631065; PMCID: PMC7953461.

Delage C, Vignal N, Guerin C, Taib T, Barboteau C, Mamma C, Khacef K, Margaill I, Sarda-Mantel L, Rizzo-Padoin N, Hontonnou F, Marchand-Leroux C, Lerouet D, Hosten B, Besson V. From positron emission tomography to cell analysis of the 18-kDa Translocator Protein in mild traumatic brain injury. Sci Rep. (2021) 11(1): 24009. PMID: 34907268; PMCID: PMC8671393

Delage C, Taib T, Mamma C, Lerouet D, Besson VC. Traumatic brain injury: an age-dependent view of post-traumatic neuroinflammation and its treatment. Pharmaceutics. 2021 Oct; 13 (10): 1624. PMID: 34683918; PMCID: PMC8537402

Gómez Morillas A, Besson VC, Lerouet D. Microglia and neuroinflammation: what place for P2RY12? Int J Mol Sci. 2021 Feb; 22 (4): 1636. PMID: 33561958; PMCID: PMC7915979

Lerouet D, Marchand-Leroux C, Besson VC. Neuropharmacology in traumatic brain injury: from preclinical to clinical neuroprotection. Fundam Clin Pharmacol. 2021 Jun; 35 (3): 524-38. PMID: 33527472; PMCID: PMC9290810

Corne R, Besson V, Ait Si Slimane S, Coutan M, Palhas MLC, Shen FX, Marchand-Leroux C, Ogier M, Mongeau R. Insulin-like growth factors may be markers of both traumatic brain injury and fear-related stress. Neuroscience. 2021 Jul; 466: 205-21. PMID: 33895341

Bonnin P, Vitalis T, Schwendimann L, Boutigny A, Mohamedi N, Besson VC, Charriaut-Marlangue C. Poly(ADP-Ribose) polymerase inhibitor PJ34 reduces brain damage after stroke in the neonatal mouse brain. Curr Issues Mol Biol. 2021 Jun; 43 (1): 301-12. PMID: 34200155 PMCID: PMC8929080

Dauré C, Fortias M, Icick R, Delage C, Bloch V, Avril E, Vorspan F. Oral long acting antipsychotic penfluridol as a harm reduction treatment in a patient suffering from untreated schizophrenia and multiple drug dependence: A case report. Psychiatry Res. 2021 Oct;304:114147. PMID: 34371297.

Clergue-Duval V, Azuar J, Fonsart J, Delage C, Rollet D, Amami J, Frapsauce A, Gautron MA, Hispard E, Bellivier F, Bloch V, Laplanche JL, Questel F, Vorspan F. Ascorbic Acid Deficiency Prevalence and Associated Cognitive Impairment in Alcohol Detoxification Inpatients: A Pilot Study. Antioxidants (Basel). 2021 Nov 26;10(12):1892. PMID: 34942994; PMCID: PMC8750659.

Delage C, Lelong H, Brion F, Blacher J. Effect of a pharmacist-led educational intervention on clinical outcomes: a randomised controlled study in patients with hypertension, type 2 diabetes and hypercholesterolaemia. Eur J Hosp Pharm. 2021 Nov;28(Suppl 2):e197-e202. PMID: 34183458; PMCID: PMC8640406.

Larréché S, Chippaux JP, Chevillard L, Mathé S, Résière D, Siguret V, Mégarbane B. Bleeding and Thrombosis: Insights into Pathophysiology of Bothrops Venom-Related Hemostasis Disorders. Int J Mol Sci. 2021 Sep 6;22(17):9643. doi: 10.3390/ijms22179643. PMID: 34502548; PMCID: PMC8431793.

Balakirouchenane D, Khoudour N, Chouchana L, Chevillard L, Parat S, Declèves X. Pharmacokinetics of Baclofen in a Full-Term Newborn after Intrauterine Exposure: A Case Report. Neonatology. 2021;118(5):624-627. doi: 10.1159/000518657. Epub 2021 Sep 23. PMID: 34569533.

Luo H, Chevillard L, Bellivier F, Mégarbane B, Etain B, Cisternino S, Declèves X. The role of brain barriers in the neurokinetics and pharmacodynamics of lithium. Pharmacol Res. 2021 Apr;166:105480. doi: 10.1016/j.phrs.2021.105480. Epub 2021 Feb 4. PMID: 33549730.

Auvity S, Goutal S, Caillé F, Vodovar D, Pruvost A, Wimberley C, Leroy C, Tonietto M, Bottlaender M, Tournier N. Pharmacokinetic neuroimaging to study the dose-related brain kinetics and target engagement of buprenorphine in vivo. Neuropsychopharmacology. 2021 May;46(6):1220-1228. doi: 10.1038/s41386-021-00976-w. Epub 2021 Feb 18. PMID: 33603137; PMCID: PMC8115308.

Schicchi A, Mégarbane B. Toxicity resulting from colchicine used to treat COVID-19 patients: a new challenge for clinical toxicologists. Clin Toxicol (Phila). 2021 Dec;59(12):1274-1275. doi: 10.1080/15563650.2021.1904141. Epub 2021 Mar 26. PMID: 33769172.

Caré W, Foissaud V, Lefeuvre L, Daban JL, Vodovar D, Aletti M, Doutrelon C. Direct oral anticoagulant plasma level measurement in clinical practice: A French single-institution retrospective study. Thromb Res. 2021 Apr;200:83-86. doi: 10.1016/j.thromres.2021.01.021. Epub 2021 Feb 2. PMID: 33549898.

Martin GC, Le Roux G, Guindolet D, Boulanger E, Hasle D, Morin E, Vodovar D, Vignal C, Gabison E, Descatha A; French PCC Research Group. Pediatric Eye Injuries by Hydroalcoholic Gel in the Context of the Coronavirus Disease 2019 Pandemic. JAMA Ophthalmol. 2021 Mar 1;139(3):348-351. doi: 10.1001/jamaophthalmol.2020.6346. Erratum in: JAMA Ophthalmol. 2021 Jul 15;: PMID: 33475712; PMCID: PMC7821077.

Caré W, Larréché S, Busser P, Dufayet L, Vodovar D, de Haro L, Langrand J. Envenomation by Centruroides pococki scorpion with neuromuscular toxicity. Toxicon. 2021 Jan 30;190:39-40. doi: 10.1016/j.toxicon.2020.12.005. Epub 2020 Dec 13. PMID: 33321147.

Voicu S, Goury A, Lacoste-Palasset T, Malissin I, Fanet L, Souissi S, Busto J, Legros V, Sutterlin L, Naim G, M'Rad A, Pepin-Lehaleur A, Deye N, Mourvillier B, Mégarbane B. Dismal Survival in COVID-19 Patients Requiring ECMO as Rescue Therapy after Corticosteroid Failure. J Pers Med. 2021 Nov 22;11(11):1238. doi: 10.3390/jpm11111238. PMID: 34834590; PMCID: PMC8622434.

Chelly J et al. ACICOVID-19 study group. Incidence, clinical characteristics, and outcome after unexpected cardiac arrest among critically ill adults with COVID-19: insight from the multicenter prospective ACICOVID-19 registry. Ann Intensive Care. 2021 Nov 13;11(1):155. doi: 10.1186/s13613-021-00945-y. PMID: 34773516; PMCID: PMC8590126.

Contou D et al. HOPEFUL Study group. Clinical phenotype and outcomes of pneumococcal versus meningococcal purpura fulminans: a multicenter retrospective cohort study. Crit Care. 2021 Nov 11;25(1):386. doi: 10.1186/s13054-021-03812-1. PMID: 34763715; PMCID: PMC8582106.

Laredo M, Curis E, Masson-Fron E, Voicu S, Mégarbane B. Does COVID-19 alter the oxyhemoglobin dissociation curve? - An observational cohort study using a mixed-effect modelling. Clin Chem Lab Med. 2021 Jun 21;59(11):e416-e419. doi: 10.1515/cclm-2021-0387. PMID: 34144638.

Bellut H, Porcher R, Varon E, Asfar P, Le Tulzo Y, Megarbane B, Mathonnet A, Dugard A, Veinstein A, Ouchenir K, Siami S, Reignier J, Galbois A, Cousson J, Preau S, Baldesi O, Rigaud JP, Souweine B, Misset B, Jacobs F, Dewavrin F, Mira JP, Bedos JP. Comparison of prognostic factors between bacteraemic and non- bacteraemic critically ill immunocompetent patients in community-acquired severe pneumococcal pneumonia: a STREPTOGENE sub-study. Ann Intensive Care. 2021 Oct 24;11(1):148. doi: 10.1186/s13613-021-00936-z. PMID: 34689255; PMCID: PMC8542522.

Labbé V et al. FAST Study Group. Transesophageal echocardiography for cardiovascular risk estimation in patients with sepsis and new-onset atrial fibrillation: a multicenter prospective pilot study. Ann Intensive Care. 2021 Oct 18;11(1):146. doi: 10.1186/s13613-021-00934-1. PMID: 34661761; PMCID: PMC8523595.

Cottereau G, Messika J, Megarbane B, Guérin L, da Silva D, Bornstain C, Santos M, Ricard JD, Sztrymf B. Handgrip strength to predict extubation outcome: a prospective multicenter trial. Ann Intensive Care. 2021 Oct 2;11(1):144. doi: 10.1186/s13613-021-00932-3. PMID: 34601639; PMCID: PMC8487340.

Ghannoum M et al. EXTRIP workgroup. Recommendations from the EXTRIP workgroup on extracorporeal treatment for baclofen poisoning. Kidney Int. 2021 Oct;100(4):720-736. doi: 10.1016/j.kint.2021.07.014. Epub 2021 Aug 4. PMID: 34358487.

Amarsy R, Jacquier H, Munier AL, Merimèche M, Berçot B, Mégarbane B. Outbreak of NDM-1-producing Klebsiella pneumoniae in the intensive care unit during the COVID-19 pandemic: Another nightmare. Am J Infect Control. 2021 Oct;49(10):1324-1326. doi: 10.1016/j.ajic.2021.07.004. Epub 2021 Jul 15. PMID: 34273465; PMCID: PMC8279923.

Gouda AS, Adbelruhman FG, Sabbah Alenezi H, Mégarbane B. Theoretical benefits of yogurt-derived bioactive peptides and probiotics in COVID-19 patients - A narrative review and hypotheses. Saudi J Biol Sci. 2021 Oct;28(10):5897-5905. doi: 10.1016/j.sjbs.2021.06.046. Epub 2021 Jun 18. PMID: 34177317; PMCID: PMC8213517.

de Roquetaillade C, Mansouri S, Brumpt C, Neuwirth M, Voicu S, Le Dorze M, Fontaine C, Barthélémy R, Gayat E, Megarbane B, Mebazaa A, Chousterman BG. Comparison of Circulating Immune Cells Profiles and Kinetics Between Coronavirus Disease 2019 and Bacterial Sepsis. Crit Care Med. 2021 Oct 1;49(10):1717-1725. doi: 10.1097/CCM.0000000000005088. PMID: 34001691.

Jung C et al. COVIP Study Group. Differences in mortality in critically ill elderly patients during the second COVID-19 surge in Europe. Crit Care. 2021 Sep 23;25(1):344. doi: 10.1186/s13054-021-03739-7. PMID: 34556171; PMCID: PMC8459701.

Buetti N, Mimoz O, Mermel L, Ruckly S, Mongardon N, Dupuis C, Mira JP, Lucet JC, Mégarbane B, Bailly S, Parienti JJ, Timsit JF. Ultrasound Guidance and Risk for Central Venous Catheter-Related Infections in the Intensive Care Unit: A Post Hoc Analysis of Individual Data of 3 Multicenter Randomized Trials. Clin Infect Dis. 2021 Sep 7;73(5):e1054-e1061. doi: 10.1093/cid/ciaa1817. PMID: 33277646.

Mégarbane B, Bourasset F, Scherrmann JM. Is Curfew Effective in Limiting SARS-CoV-2 Progression? An Evaluation in France Based on Epidemiokinetic Analyses. J Gen Intern Med. 2021 Sep;36(9):2731-2738. doi: 10.1007/s11606-021-06953-9. Epub 2021 Jun 15. PMID: 34131877; PMCID: PMC8205314.

Vodovar D, Peyre H, Mégarbane B. Relationship between acute kidney injury and mortality in poisoning - a systematic review and metanalysis. Clin Toxicol (Phila). 2021 Sep;59(9):771-779. doi: 10.1080/15563650.2021.1928161. Epub 2021 Jun 3. PMID: 34080503.

Rouzé A et al. coVAPid Study Group. Early Bacterial Identification among Intubated Patients with COVID-19 or Influenza Pneumonia: A European Multicenter Comparative Clinical Trial. Am J Respir Crit Care Med. 2021 Sep 1;204(5):546-556. doi: 10.1164/rccm.202101-0030OC. PMID: 34038699; PMCID: PMC8491267.

Ruetsch V, Zarka J, Vanel B, Tissieres P, Megarbane B, Renolleau S, Dauger S, Guilbert AS, Leteurtre S, Charpentier J, Vaugier I, Bergounioux J. Pediatric Acute Alcohol Intoxication Admitted to the ICU: A Review of 102 Cases in France. Crit Care Med. 2021 Sep 1;49(9):e833-e839. doi: 10.1097/CCM.0000000000005032. PMID: 33870912.

Bruno RR et al. COVIP Study Group. Lactate is associated with mortality in very old intensive care patients suffering from COVID-19: results from an international observational study of 2860 patients. Ann Intensive Care. 2021 Aug 21;11(1):128. doi: 10.1186/s13613-021-00911-8. PMID: 34417919; PMCID: PMC8379577.

Bastard P et al. COVID Clinicians; COVID-STORM Clinicians; NIAID Immune Response to COVID Group; NH-COVAIR Study Group; Danish CHGE; Danish Blood Donor Study; St. James's Hospital; SARS CoV2 Interest group; French COVID Cohort Study Group; Imagine COVID-Group; Milieu Intérieur Consortium; CoV-Contact Cohort; Amsterdam UMC Covid-19; Biobank Investigators; COVID Human Genetic Effort; CONSTANCES cohort; 3C-Dijon Study; Cerba Health-Care; Etablissement du Sang study group. Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths. Sci Immunol. 2021 Aug 19;6(62):eabl4340. doi: 10.1126/sciimmunol.abl4340. PMID: 34413139; PMCID: PMC8521484.

Voiriot G et al. MULTI-CAP study group. Combined use of a broad-panel respiratory multiplex PCR and procalcitonin to reduce duration of antibiotics exposure in patients with severe community-acquired pneumonia (MULTI-CAP): a multicentre, parallel-group, open-label, individual randomised trial conducted in French intensive care units. BMJ Open. 2021 Aug 18;11(8):e048187. doi: 10.1136/bmjopen-2020-048187. PMID: 34408046; PMCID: PMC8375718.

Nseir S et al. coVAPid study group. Correction to: Relationship between ventilator-associated pneumonia and mortality in COVID-19 patients: a planned ancillary analysis of the coVAPid cohort. Crit Care. 2021 Aug 9;25(1):284. doi: 10.1186/s13054-021-03713-3. Erratum for: Crit Care. 2021 May 25;25(1):177. PMID: 34372897; PMCID: PMC8350264.

Arabi YM et al. REMAP-CAP Investigators. Lopinavir-ritonavir and hydroxychloroquine for critically ill patients with COVID-19: REMAP-CAP randomized controlled trial. Intensive Care Med. 2021 Aug;47(8):867-886. doi: 10.1007/s00134-021-06448-5. Epub 2021 Jul 12. PMID: 34251506; PMCID: PMC8274471.

Vodovar D, Mégarbane B. Does MARS™ beneficially affect hemodynamics in refractory vasoplegic shock due to calcium-channel blocker poisoning? Evidence is missing. Int J Artif Organs. 2021 Aug;44(8):527-528. doi: 10.1177/03913988211019757. Epub 2021 May 25. PMID: 34030501.

Lebreton G et al. Paris ECMO-COVID-19 investigators. Extracorporeal membrane oxygenation network organisation and clinical outcomes during the COVID-19 pandemic in Greater Paris, France: a multicentre cohort study. Lancet Respir Med. 2021 Aug;9(8):851-862. doi: 10.1016/S2213-2600(21)00096-5. Epub 2021 Apr 19. Erratum in: Lancet Respir Med. 2021 Jun;9(6):e55. Erratum in: Lancet Respir Med. 2021 Jul;9(7):e62. PMID: 33887246; PMCID: PMC8055207.

Boels D, Mégarbane B, Bouquié R. Delayed and prolonged coma following valpromide poisoning in a 4-year-old girl. Clin Toxicol (Phila). 2021 Aug;59(8):763-764. doi: 10.1080/15563650.2020.1853144. Epub 2020 Dec 4. PMID: 33274655.

Leconte C, Benedetto C, Lentini F, Simon K, Ouaazizi C, Taib T, Cho A, Plotkine M, Mongeau R, Marchand-Leroux C, Besson VC. Histological and behavioral evaluation after mild traumatic brain injury in mice: a ten months follow-up study. J Neurotrauma. 2020 Jun; 37 (11) : 1342-57. PMID: 31830858

Mégarbane B, Zammit M, Lonati D. Management of caustic ingestion: the time has come for consensus guidelines. Clin Toxicol (Phila). 2021 Aug;59(8):765-766. doi: 10.1080/15563650.2020.1853147. Epub 2020 Dec 2. PMID: 33263450.

Morel G, Mulier G, Ghrenassia E, Abdel Nabey M, Tandjaoui Y, Kouatchet A, Platon L, Pène F, Moreau AS, Seguin A, Contou D, Sonneville R, Rousset D, Picard M, Dumas G, Mokart D, Megarbane B, Voiriot G, Oddou I, Azoulay E, Biard L, Zafrani L. Non-C. difficile Clostridioides Bacteremia in Intensive Care Patients, France. Emerg Infect Dis. 2021 Jul;27(7):1840-1849. doi: 10.3201/eid2707.203471. PMID: 34153220; PMCID: PMC8237868.

Delrue M, Siguret V, Neuwirth M, Brumpt C, Voicu S, Burlacu R, Sène D, Chousterman BG, Mohamedi N, Lecompte T, Mégarbane B, Stépanian A. Contrast between Prevalence of HIT Antibodies and Confirmed HIT in Hospitalized COVID-19 Patients: A Prospective Study with Clinical Implications. Thromb Haemost. 2021 Jul;121(7):971-975. doi: 10.1055/a-1333-4688. Epub 2021 Jan 27. PMID: 33296940.

Fabresse N, Larabi IA, Lamy E, Mégarbane B, Alvarez JC. Molecular adsorbent recirculating system (MARS) and continuous veno-venous hemodiafiltration (CVVHDF) for diltiazem removal: An in vitro study. Int J Artif Organs. 2021 Jul;44(7):489-496. doi: 10.1177/0391398820975041. Epub 2020 Dec 1. PMID: 33258721.

Vodovar D, Tournier N, Mégarbane B. Ventilatory depression following oral buprenorphine exposure: insight into the involved mechanisms. Clin Toxicol (Phila). 2021 Jul;59(7):677-679. doi: 10.1080/15563650.2020.1837858. Epub 2020 Nov 2. PMID: 33135497.

Dankiewicz J et al. TTM2 Trial Investigators. Hypothermia versus Normothermia after Out-of-Hospital Cardiac Arrest. N Engl J Med. 2021 Jun 17;384(24):2283-2294. doi: 10.1056/NEJMoa2100591. PMID: 34133859.

Bouchard J et al. EXTRIP workgroup. Extracorporeal treatment for poisoning to beta-adrenergic antagonists: systematic review and recommendations from the EXTRIP workgroup. Crit Care. 2021 Jun 10;25(1):201. doi: 10.1186/s13054-021-03585-7. PMID: 34112223; PMCID: PMC8194226.

Nuzzo A, Salem S, Malissin I, Diallo A, Deye N, Goury A, Gourlain H, Péron N, Vicaut E, Voicu S, Mégarbane B. Plasma procalcitonin may be an early predictor of liver injury in acetaminophen poisoning: A prospective cohort study. United European Gastroenterol J. 2021 Jun;9(5):571-580. doi: 10.1002/ueg2.12093. PMID: 34181312; PMCID: PMC8259278.

Vanderbeke L et al. Dutch-Belgian Mycosis Study Group. Posaconazole for prevention of invasive pulmonary aspergillosis in critically ill influenza patients (POSA-FLU): a randomised, open-label, proof-of-concept trial. Intensive Care Med. 2021 Jun;47(6):674-686. doi: 10.1007/s00134-021-06431-0. Epub 2021 May 29. PMID: 34050768; PMCID: PMC8164057.

Gouda AS, Adbelruhman FG, Elbendary RN, Alharbi FA, Alhamrani SQ, Mégarbane B. A comprehensive insight into the role of zinc deficiency in the renin- angiotensin and kinin-kallikrein system dysfunctions in COVID-19 patients. Saudi J Biol Sci. 2021 Jun;28(6):3540-3547. doi: 10.1016/j.sjbs.2021.03.027. Epub 2021 Mar 16. PMID: 33746538; PMCID: PMC7962980.

Kevorkian JP, Lopes A, Sène D, Riveline JP, Vandiedonck C, Féron F, Nassarmadji K, Mouly S, Mauvais-Jarvis F, Gautier JF, Mégarbane B. Oral corticoid, aspirin, anticoagulant, colchicine, and furosemide to improve the outcome of hospitalized COVID-19 patients - the COCAA-COLA cohort study. J Infect. 2021 Jun;82(6):276-316. doi: 10.1016/j.jinf.2021.02.008. Epub 2021 Feb 9. PMID: 33577902; PMCID: PMC7871882.

Angrand L, Takillah S, Malissin I, Berriche A, Cervera C, Bel R, Gerard Q, Knoertzer J, Baati R, Kononchik JP, Megarbane B, Thibault K, Dal Bo G. Persistent brainwave disruption and cognitive impairment induced by acute sarin surrogate sub-lethal dose exposure. Toxicology. 2021 May 30;456:152787. doi: 10.1016/j.tox.2021.152787. Epub 2021 Apr 19. PMID: 33887375.

Nakhaee S, Farrokhfall K, Miri-Moghaddam E, Foadoddini M, Askari M, Amirabadizadeh A, Brent J, Megarbane B, Mehrpour O. The effects of naloxone, diazepam, and quercetin on seizure and sedation in acute on chronic tramadol administration: an experimental study. Behav Brain Funct. 2021 May 29;17(1):5. doi: 10.1186/s12993-021-00178-w. PMID: 34051813; PMCID: PMC8164767.

Nseir S et al. coVAPid study group. Relationship between ventilator-associated pneumonia and mortality in COVID-19 patients: a planned ancillary analysis of the coVAPid cohort. Crit Care. 2021 May 25;25(1):177. doi: 10.1186/s13054-021-03588-4. Erratum in: Crit Care. 2021 Aug 9;25(1):284. PMID: 34034777; PMCID: PMC8146175.

Dres M et al. COVID-ICU investigators. Characteristics, management, and prognosis of elderly patients with COVID-19 admitted in the ICU during the first wave: insights from the COVID-ICU study : Prognosis of COVID-19 elderly critically ill patients in the ICU. Ann Intensive Care. 2021 May 14;11(1):77. doi: 10.1186/s13613-021-00861-1. PMID: 33988767; PMCID: PMC8120254.

Resiere D, Mehdaoui H, Dyer H, Chabartier C, Cabié A, Inamo J, Compton K, Neviere R, Megarbane B, Kallel H. Covid-19 in the Caribbean: lessons learned from the ongoing international medical and scientific cooperation. Global Health. 2021 May 10;17(1):55. doi: 10.1186/s12992-021-00706-3. PMID: 33971911; PMCID: PMC8107407.

Mowry JB et al. Extracorporeal Treatments in Poisoning workgroup. Extracorporeal treatments for isoniazid poisoning: Systematic review and recommendations from the EXTRIP workgroup. Pharmacotherapy. 2021 May;41(5):463-478. doi: 10.1002/phar.2519. Epub 2021 Apr 3. PMID: 33660266.

Mang S et al. COVEC-Study Group. Extracorporeal life support in COVID-19-related acute respiratory distress syndrome: A EuroELSO international survey. Artif Organs. 2021 May;45(5):495-505. doi: 10.1111/aor.13940. Epub 2021 Mar 28. PMID: 33590542; PMCID: PMC8014805.

Wong A et al. EXTRIP workgroup. Extracorporeal treatment for calcium channel blocker poisoning: systematic review and recommendations from the EXTRIP workgroup. Clin Toxicol (Phila). 2021 May;59(5):361-375. doi: 10.1080/15563650.2020.1870123. Epub 2021 Feb 8. PMID: 33555964.

2020

Voicu S, Chousterman BG, Bonnin P, Deye N, Malissin I, Gall AL, Barthélémy R, Sutterlin L, Naim G, Mrad A, Pepin-Lehalleur A, Dorze ML, de Roquetaillade C, Ekhérian JM, Gayat E, Sidéris G, Mebazaa A, Mégarbane B. Increased anticoagulation reduces proximal deep vein thrombosis in mechanically ventilated COVID-19 patients: Venous thrombosis prevention & COVID-19. J Infect. 2021 May;82(5):186-230. doi: 10.1016/j.jinf.2020.11.019. Epub 2020 Nov 20. PMID: 33227338; PMCID: PMC7677679.

Dufayet L, Monnet F, Laborde-Casterot H, Caré W, Lekens B, Langrand J; French Poison Control Centers Research Network; Mégarbane B, Vodovar D. Unintentional exposure to pregabalin in ≤6-year-old children: a nationwide French Poison Control Center study. Clin Toxicol (Phila). 2021 May;59(5):433-439. doi: 10.1080/15563650.2020.1822530. Epub 2020 Oct 2. PMID: 33006482.

Declercq PL, Eraldi JP, Beuzelin M, Gélinotte S, Marchalot A, Bougerol F, Allorge D, Loriot MA, Paret N, Mégarbane B, Rigaud JP. Severe serotonin syndrome caused by an interaction between an antidepressant and a cough syrup. Therapie. 2021 May-Jun;76(3):249-252. doi: 10.1016/j.therap.2020.02.020. Epub 2020 Feb 26. PMID: 32192714.

REMAP-CAP Investigators. Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19. N Engl J Med. 2021 Apr 22;384(16):1491-1502. doi: 10.1056/NEJMoa2100433. Epub 2021 Feb 25. PMID: 33631065; PMCID: PMC7953461.

Jung C et al. COVIP study group. The impact of frailty on survival in elderly intensive care patients with COVID-19: the COVIP study. Crit Care. 2021 Apr 19;25(1):149. doi: 10.1186/s13054-021-03551-3. PMID: 33874987; PMCID: PMC8054503.

Echeverry-Alzate V, Jeanblanc J, Sauton P, Bloch V, Labat L, Soichot M, Vorspan F, Naassila M. Is R(+)-Baclofen the best option for the future of Baclofen in alcohol dependence pharmacotherapy? Insights from the preclinical side. Addict Biol. 2021 Mar;26(2):e12892. doi: 10.1111/adb.12892. Epub 2020 Mar 8. PMID: 32146727.

Benichou N, Lebbah S, Hajage D, Martin-Lefèvre L, Pons B, Boulet E, Boyer A, Chevrel G, Lerolle N, Carpentier D, de Prost N, Lautrette A, Bretagnol A, Mayaux J, Nseir S, Megarbane B, Thirion M, Forel JM, Maizel J, Yonis H, Markowicz P, Thiery G, Schortgen F, Tubach F, Ricard JD, Dreyfuss D, Gaudry S. Vascular access for renal replacement therapy among 459 critically ill patients: a pragmatic analysis of the randomized AKIKI trial. Ann Intensive Care. 2021 Apr 8;11(1):56. doi: 10.1186/s13613-021-00843-3. PMID: 33830370; PMCID: PMC8032839.

Vodovar D, Megarbane B. Complications neurologiques du lithium : le point de vue du toxicologue [Neurological complications of lithium: The clinical toxicologist perspective]. Rev Med Interne. 2021 Apr;42(4):294-295. French. doi: 10.1016/j.revmed.2021.03.001. Epub 2021 Mar 25. PMID: 33773850.

Demiselle J, Seegers V, Lemerle M, Meziani F, Grelon F, Megarbane B, Anguel N, Mira JP, Dequin PF, Gergaud S, Weiss N, Legay F, Le Tulzo Y, Conrad M, Robert R, Gonzalez F, Guitton C, Tamion F, Tonnelier JM, Bédos JP, Van Der Linden T, Vieillard-Baron A, Mariotte E, Pradel G, Lesieur O, Ricard JD, Hervé F, du Cheyron D, Guerin C, Teboul JL, Helms J, Radermacher P, Asfar P. Prior Exposure to Angiotensin II Receptor Blockers in Patients With Septic Shock to Individualize Mean Arterial Pressure Target? A Post Hoc Analysis of the Sepsis and Mean Arterial Pressure (SEPSISPAM) Trial. Crit Care Med. 2021 Apr 1;49(4):e412-e422. doi: 10.1097/CCM.0000000000004872. PMID: 33591012.

Alanio A, Dellière S, Voicu S, Bretagne S, Mégarbane B. The presence of Pneumocystis jirovecii in critically ill patients with COVID-19. J Infect. 2021 Apr;82(4):84-123. doi: 10.1016/j.jinf.2020.10.034. Epub 2020 Nov 4. PMID: 33157150; PMCID: PMC7609246.

Layne KA et al. Euro-DEN Plus Research Group. Acute toxicity related to misuse (nonmedical use) of tramadol: Experience of the European Drug Emergencies Network Plus. Br J Clin Pharmacol. 2021 Apr;87(4):1668-1675. doi: 10.1111/bcp.14408. Epub 2020 Jul 15. Erratum in: Br J Clin Pharmacol. 2021 Jun;87(6):2619. PMID: 32503085.

Lambrecq V et al. Cohort COVID-19 Neurosciences (CoCo Neurosciences) Study Group. Association of Clinical, Biological, and Brain Magnetic Resonance Imaging Findings With Electroencephalographic Findings for Patients With COVID-19. JAMA Netw Open. 2021 Mar 1;4(3):e211489. doi: 10.1001/jamanetworkopen.2021.1489. Erratum in: JAMA Netw Open. 2022 Jun 1;5(6):e2219899. PMID: 33720371; PMCID: PMC7961310.

Waldmann V, Karam N, Gaye B, Bougouin W, Dumas F, Sharifzadehgan A, Narayanan K, Kassim H, Beganton F, Jost D, Lamhaut L, Loeb T, Adnet F, Agostinucci JM, Deltour S, Revaux F, Ludes B, Voicu S, Megarbane B, Jabre P, Cariou A, Marijon E, Jouven X; on behalf Paris-SDEC investigators. Temporal Trends of Out-of-Hospital Cardiac Arrests Without Resuscitation Attempt by Emergency Medical Services. Circ Cardiovasc Qual Outcomes. 2021 Mar;14(3):e006626. doi: 10.1161/CIRCOUTCOMES.120.006626. Epub 2021 Mar 12. PMID: 33706541.

Seifert SA, Buckley N, Chan B, Chan TYK, Cumpston K, Kirschner RI, Megarbane B, Mullins M, Seger D, Thomas S, Vale JA, Wilks MF. Clinical Toxicology review metrics and expert reviewers, 2020. Clin Toxicol (Phila). 2021 Mar;59(3):e1-e3. doi: 10.1080/15563650.2021.1874197. PMID: 33576317.

CORIMUNO-19 Collaborative group. Effect of anakinra versus usual care in adults in hospital with COVID-19 and mild-to-moderate pneumonia (CORIMUNO- ANA-1): a randomised controlled trial. Lancet Respir Med. 2021 Mar;9(3):295-304. doi: 10.1016/S2213-2600(20)30556-7. Epub 2021 Jan 22. PMID: 33493450; PMCID: PMC7825875.

Mégarbane B, Bourasset F, Scherrmann JM. Is Lockdown Effective in Limiting SARS-CoV-2 Epidemic Progression?-a Cross-Country Comparative Evaluation Using Epidemiokinetic Tools. J Gen Intern Med. 2021 Mar;36(3):746-752. doi: 10.1007/s11606-020-06345-5. Epub 2021 Jan 13. PMID: 33442818; PMCID: PMC7806254.

Delrue M, Siguret V, Neuwirth M, Joly B, Beranger N, Sène D, Chousterman BG, Voicu S, Bonnin P, Mégarbane B, Stépanian A. von Willebrand factor/ADAMTS13 axis and venous thromboembolism in moderate-to-severe COVID-19 patients. Br J Haematol. 2021 Mar;192(6):1097-1100. doi: 10.1111/bjh.17216. Epub 2020 Dec 24. PMID: 33368196.

Resiere D, Mehdaoui H, Florentin J, Gueye P, Lebrun T, Blateau A, Viguier J, Valentino R, Brouste Y, Kallel H, Megarbane B, Cabie A, Banydeen R, Neviere R. Sargassum seaweed health menace in the Caribbean: clinical characteristics of a population exposed to hydrogen sulfide during the 2018 massive stranding. Clin Toxicol (Phila). 2021 Mar;59(3):215-223. doi: 10.1080/15563650.2020.1789162. Epub 2020 Jul 7. PMID: 32633580.

Weizman O et al. Paris-SDEC Investigators†. Sudden Cardiac Arrest in Young Women. Circulation. 2021 Feb 16;143(7):758-760. doi: 10.1161/CIRCULATIONAHA.120.052219. Epub 2021 Feb 15. PMID: 33587656.

Rouzé A et al. coVAPid study Group. Relationship between SARS-CoV-2 infection and the incidence of ventilator-associated lower respiratory tract infections: a European multicenter cohort study. Intensive Care Med. 2021 Feb;47(2):188-198. doi: 10.1007/s00134-020-06323-9. Epub 2021 Jan 3. Erratum in: Intensive Care Med. 2022 Apr;48(4):514-515. PMID: 33388794; PMCID: PMC7778569.

Gouda AS, Mégarbane B. Snake venom-derived bradykinin-potentiating peptides: A promising therapy for COVID-19? Drug Dev Res. 2021 Feb;82(1):38-48. doi: 10.1002/ddr.21732. Epub 2020 Aug 5. PMID: 32761647; PMCID: PMC7436322.

Peskine A et al. Hanox Study Group. Long-Term Disabilities of Survivors of Out-of-Hospital Cardiac Arrest: The Hanox Study. Chest. 2021 Feb;159(2):699-711. doi: 10.1016/j.chest.2020.07.022. Epub 2020 Jul 20. PMID: 32702410.

Noseda R et al. Euro-DEN Research Group. MDMA-related presentations to the emergency departments of the European Drug Emergencies Network plus (Euro-DEN Plus) over the four-year period 2014-2017. Clin Toxicol (Phila). 2021 Feb;59(2):131-137. doi: 10.1080/15563650.2020.1784914. Epub 2020 Jul 17. PMID: 32677861.

Megarbane B, Schicchi A. Management of Chloroquine and Hydroxychloroquine Poisoning: Do Not Miss the Time of Tracheal Intubation and Mechanical Ventilation. West J Emerg Med. 2021 Jan 11;22(2):454-455. doi: 10.5811/westjem.2020.10.49826. PMID: 33856339; PMCID: PMC7972374.

Voicu S, Ketfi C, Stépanian A, Chousterman BG, Mohamedi N, Siguret V, Mebazaa A, Mégarbane B, Bonnin P. Pathophysiological Processes Underlying the High Prevalence of Deep Vein Thrombosis in Critically Ill COVID-19 Patients. Front Physiol. 2021 Jan 8;11:608788. doi: 10.3389/fphys.2020.608788. PMID: 33488398; PMCID: PMC7820906.

COVID-ICU Group on behalf of the REVA Network and the COVID-ICU Investigators. Clinical characteristics and day-90 outcomes of 4244 critically ill adults with COVID-19: a prospective cohort study. Intensive Care Med. 2021 Jan;47(1):60-73. doi: 10.1007/s00134-020-06294-x. Epub 2020 Oct 29. PMID: 33211135; PMCID: PMC7674575.

Hermine O et al. CORIMUNO-19 Collaborative Group. Effect of Tocilizumab vs Usual Care in Adults Hospitalized With COVID-19 and Moderate or Severe Pneumonia: A Randomized Clinical Trial. JAMA Intern Med. 2021 Jan 1;181(1):32-40. doi: 10.1001/jamainternmed.2020.6820. Erratum in: JAMA Intern Med. 2021 Jan 1;181(1):144. Erratum in: JAMA Intern Med. 2021 Jul 1;181(7):1021. PMID: 33080017; PMCID: PMC7577198.

Mégarbane B, Scherrmann JM. Comment on: Rationale of a loading dose initiation for hydroxychloroquine treatment in COVID-19 infection in the DisCoVeRy trial. J Antimicrob Chemother. 2021 Jan 1;76(1):276-277. doi: 10.1093/jac/dkaa327. PMID: 32766679; PMCID: PMC7454555.

Mégarbane B, Schicchi A. Hydroxychloroquine Overdose: What Are the Exact Roles of Diazepam and Potassium Infusion? J Med Toxicol. 2021 Jan;17(1):83-84. doi: 10.1007/s13181-020-00809-0. Epub 2020 Sep 14. PMID: 32926302; PMCID: PMC7785597.

Kevorkian JP, Riveline JP, Vandiedonck C, Girard D, Galland J, Féron F, Gautier JF, Mégarbane B. Early short-course corticosteroids and furosemide combination to treat non-critically ill COVID-19 patients: An observational cohort study. J Infect. 2021 Jan;82(1):e22-e24. doi: 10.1016/j.jinf.2020.08.045. Epub 2020 Sep 1. PMID: 32888976; PMCID: PMC7462464.

Mégarbane B, Gamblin C, Roussel O, Bouaziz-Amar E, Chevillard L, Callebert J, Chen H, Morineau G, Laplanche JL, Etheve-Quelquejeu M, Liechti ME, Benturquia N. The neurobehavioral effects of the designer drug naphyrone - an experimental investigation with pharmacokinetics and concentration/effect relationship in mice. Psychopharmacology (Berl). 2020 Jul;237(7):1943-1957. doi: 10.1007/s00213-020-05510-2. Epub 2020 May 12. PMID: 32399634.

Mégarbane B. Chloroquine and hydroxychloroquine to treat COVID-19: between hope and caution. Clin Toxicol (Phila). 2021 Jan;59(1):70-71. doi: 10.1080/15563650.2020.1748194. Epub 2020 Apr 2. PMID: 32237918.

Grossenbacher F, Giodarno Orsini G, Cazaubon Y, Fouret P, Djerada Z, Mégarbane B. Myocardial infarction in relation to colchicine poisoning: A precipitating cause of refractory toxic cardiogenic shock. Therapie. 2021 Jan- Feb;76(1):51-53. doi: 10.1016/j.therap.2019.12.012. Epub 2020 Jan 13. PMID: 31992453.

Boels D, Mahe J, Olry A, Citerrio-Quentin A, Moragny J, Jolliet P. Fatal and life-threatening ADRs associated with paliperidone palmitate: an observational study in the French Pharmacovigilance Database, Clin Toxicol (Phila), 2021 Sep;59(9):786-793. doi: 10.1080/15563650.2021.1878206.

Dellière S, Dudoignon E, Fodil S, Voicu S, Collet M, Oillic PA, Salmona M, Dépret F, Ghelfenstein-Ferreira T, Plaud B, Chousterman B, Bretagne S, Azoulay E, Mebazaa A, Megarbane B, Alanio A. Risk factors associated with COVID-19-associated pulmonary aspergillosis in ICU patients: a French multicentric retrospective cohort. Clin Microbiol Infect. 2020 Dec 13;27(5):790.e1–5. doi: 10.1016/j.cmi.2020.12.005. Epub ahead of print. PMID: 33316401; PMCID: PMC7733556.

Ferron PJ, Gicquel T, Mégarbane B, Clément B, Fromenty B. Treatments in Covid-19 patients with pre-existing metabolic dysfunction-associated fatty liver disease: A potential threat for drug-induced liver injury? Biochimie. 2020 Dec;179:266-274. doi: 10.1016/j.biochi.2020.08.018. Epub 2020 Sep 3. PMID: 32891697; PMCID: PMC7468536.

de Charentenay L et al. Antigone Investigators. Outcomes in 886 Critically Ill Patients After Near-Hanging Injury. Chest. 2020 Dec;158(6):2404-2413. doi: 10.1016/j.chest.2020.07.064. Epub 2020 Aug 3. PMID: 32758563.

Vodovar D, Lê MP, Labat L, Mégarbane B. Identifying lithium-poisoned patients who may benefit from haemodialysis remains highly challenging. Br J Clin Pharmacol. 2020 Dec;86(12):2542-2543. doi: 10.1111/bcp.14366. Epub 2020 Jun 2. PMID: 32483848; PMCID: PMC7688526.

Mégarbane B, Oberlin M, Alvarez JC, Balen F, Beaune S, Bédry R, Chauvin A, Claudet I, Danel V, Debaty G, Delahaye A, Deye N, Gaulier JM, Grossenbacher F, Hantson P, Jacobs F, Jaffal K, Labadie M, Labat L, Langrand J, Lapostolle F, Le Conte P, Maignan M, Nisse P, Sauder P, Tournoud C, Vodovar D, Voicu S, Claret PG, Cerf C. Management of pharmaceutical and recreational drug poisoning. Ann Intensive Care. 2020 Nov 23;10(1):157. doi: 10.1186/s13613-020-00762-9. PMID: 33226502; PMCID: PMC7683636.

Azoulay E, Cariou A, Bruneel F, Demoule A, Kouatchet A, Reuter D, Souppart V, Combes A, Klouche K, Argaud L, Barbier F, Jourdain M, Reignier J, Papazian L, Guidet B, Géri G, Resche-Rigon M, Guisset O, Labbé V, Mégarbane B, Van Der Meersch G, Guitton C, Friedman D, Pochard F, Darmon M, Kentish-Barnes N. Symptoms of Anxiety, Depression, and Peritraumatic Dissociation in Critical Care Clinicians Managing Patients with COVID-19. A Cross-Sectional Study. Am J Respir Crit Care Med. 2020 Nov 15;202(10):1388-1398. doi: 10.1164/rccm.202006-2568OC. PMID: 32866409; PMCID: PMC7667906.

Vorspan F, Icick R, Mekdad N, Courtin C, Bloch V, Bellivier F, Laplanche JL, Prince N, Pishalin D, Firmo C, Blugeon C, Mégarbane B, Marie-Claire C, Benturquia N. Translational study of the whole transcriptome in rats and genetic polymorphisms in humans identifies LRP1B and VPS13A as key genes involved in tolerance to cocaine-induced motor disturbances. Transl Psychiatry. 2020 Nov 6;10(1):381. doi: 10.1038/s41398-020-01050-7. PMID: 33159041; PMCID: PMC7648099.

Fontaine C, Lemiale V, Resche-Rigon M, Schenck M, Chelly J, Geeraerts T, Hamdi A, Guitton C, Meziani F, Lefrant JY, Megarbane B, Mentec H, Chaffaut C, Cariou A, Legriel S; HYBERNATUS Study Group. Association of systemic secondary brain insults and outcome in patients with convulsive status epilepticus: A post hoc study of a randomized controlled trial. Neurology. 2020 Nov 3;95(18):e2529-e2541. doi: 10.1212/WNL.0000000000010726. Epub 2020 Sep 10. PMID: 32913029.

Deye N, Nguyen P, Vodovar N, Sadoune M, Collet C, Voicu S, Malissin I, Gayat E, Samuel JL, Delcayre C, Launay JM, Cohen-Solal A, Mégarbane B, Mebazaa A. Protein S100B as a reliable tool for early prognostication after cardiac arrest. Resuscitation. 2020 Nov;156:251-259. doi: 10.1016/j.resuscitation.2020.08.010. Epub 2020 Aug 25. PMID: 32858156.

Wargny M et al. CORONADO investigators. Type 1 Diabetes in People Hospitalized for COVID-19: New Insights From the CORONADO Study. Diabetes Care. 2020 Nov;43(11):e174-e177. doi: 10.2337/dc20-1217. Epub 2020 Aug 26. PMID: 32847826; PMCID: PMC7576421.

Siguret V, Voicu S, Neuwirth M, Delrue M, Gayat E, Stépanian A, Mégarbane B. Are antiphospholipid antibodies associated with thrombotic complications in critically ill COVID-19 patients? Thromb Res. 2020 Nov;195:74-76. doi: 10.1016/j.thromres.2020.07.016. Epub 2020 Jul 8. PMID: 32663703; PMCID: PMC7342042.

Amarsy R, Pean de Ponfilly GR, Benmansour HA, Jacquier H, Cambau EE, Mégarbane B. Serratia marcescens outbreak in the intensive care unit during the COVID-19 pandemic: A paradoxical risk? Med Mal Infect. 2020 Nov;50(8):750-751. English. doi: 10.1016/j.medmal.2020.05.004. Epub 2020 May 21. PMID: 32446986; PMCID: PMC7241335.

Angus DC et al. Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19: The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial. JAMA. 2020 Oct 6;324(13):1317-1329. doi: 10.1001/jama.2020.17022. PMID: 32876697; PMCID: PMC7489418.

Berling I et al. EXTRIP workgroup. Extracorporeal Treatment for Chloroquine, Hydroxychloroquine, and Quinine Poisoning: Systematic Review and Recommendations from the EXTRIP Workgroup. J Am Soc Nephrol. 2020 Oct;31(10):2475-2489. doi: 10.1681/ASN.2020050564. Epub 2020 Sep 22. PMID: 32963091; PMCID: PMC7609009.

Voicu S, Bajoras V, Gall E, Deye N, Malissin I, Dillinger JG, Benajiba C, Logeart D, Henry P, Megarbane B, Sideris G. Immediate coronary angiogram in out- of-hospital cardiac arrest patients with non-shockable initial rhythm and without ST-segment elevation - Is there a clinical benefit? Resuscitation. 2020 Oct;155:226-233. doi: 10.1016/j.resuscitation.2020.06.022. Epub 2020 Jul 3. PMID: 32629093.

Dufayet L, Caré W, de Haro L, Ameltchenko M, Knezynski M, Vodovar D, Langrand J. Acute occupational exposure to holothurians (Cucumaria frondosa) resulting in irritating symptoms: About three cases. Toxicon. 2021 Jan 15;189:45-47. doi: 10.1016/j.toxicon.2020.11.006. Epub 2020 Nov 17. PMID: 33212098.

Laborde-Castérot H, Darrouzet E, Le Roux G, Labadie M, Delcourt N, de Haro L, Vodovar D, Langrand J; French Poison Control Centers Research Group. Ocular Lesions Other Than Stings Following Yellow-Legged Hornet (Vespa velutina nigrithorax) Projections, as Reported to French Poison Control Centers. JAMA Ophthalmol. 2021 Jan 1;139(1):105-108. doi: 10.1001/jamaophthalmol.2020.4877. Erratum in: JAMA Ophthalmol. 2021 Jul 15;:null. PMID: 33180111; PMCID: PMC7662492.

Rogliano PF, Voicu S, Labat L, Deye N, Malissin I, Laplanche JL, Vodovar D, Mégarbane B. Acute Poisoning with Rhabdomyolysis in the Intensive Care Unit: Risk Factors for Acute Kidney Injury and Renal Replacement Therapy Requirement. Toxics. 2020 Sep 28;8(4):79. doi: 10.3390/toxics8040079. PMID: 32998294; PMCID: PMC7711436.

Voicu S, Delrue M, Chousterman BG, Stépanian A, Bonnin P, Malissin I, Deye N, Neuwirth M, Ketfi C, Mebazaa A, Siguret V, Mégarbane B. Imbalance between procoagulant factors and natural coagulation inhibitors contributes to hypercoagulability in the critically ill COVID-19 patient: clinical implications. Eur Rev Med Pharmacol Sci. 2020 Sep;24(17):9161-9168. doi: 10.26355/eurrev_202009_22866. PMID: 32965009.

Laborde-Casterot H, Larabi IA, Dufayet L, Etting I, Alvarez JC, Vodovar D. Does cannabidiol induce cannabinoid hyperemesis syndrome? Clin Toxicol (Phila). 2020 Dec;58(12):1351-1352. doi: 10.1080/15563650.2020.1736298. Epub 2020 Mar 12. PMID: 32163300.

Vodovar D, Ricard JD, Zafrani L, Weiss E, Desrentes E, Roux D. Évaluation d’un enseignement multimodal intégrant du e-learning dans l’apprentissage de la réanimation et de la médecine d’urgence au cours du second cycle des études médicales [Assessment of a newly-implemented blended teaching of intensive care and emergency medicine at Paris-Diderot University]. Rev Med Interne. 2020 Jun;41(6):368-374. French. doi: 10.1016/j.revmed.2019.12.021. Epub 2020 Jan 31. PMID: 32008801.

Torrents R, Glaizal M, Sinno-Tellier S, Richard N, Nisse P, Vodovar D, Bloch J, Simon N, de Haro L. Methadone poisonings: a seven-year retrospective study of the French poison center network focusing on suicide attempts vs. misuses. Fundam Clin Pharmacol. 2020 Apr;34(2):290-295. doi: 10.1111/fcp.12506. Epub 2019 Oct 6. PMID: 31498916.

Corne R, Leconte C, Ouradou M, Fassina V, Zhu Y, Déou E, Besson V, Plotkine M, Marchand-Leroux C, Mongeau R. Spontaneous resurgence of conditioned fear weeks after successful extinction in brain injured mice. Prog Neuropsychopharmacol Biol Psychiatry. 2019 Jan; 88: 276-86. PMID: 30096331

Villapol S, Faivre V, Joshi P, Moretti R, Besson VC^#, Charriaut-Marlangue C^#. Early Sex Differences in the Immune-Inflammatory Responses to Neonatal Ischemic Stroke. Int J Mol Sci. 2019 Aug; 20(15). pii: E3809. ^#contribution égale PMID: 31382688; PMCID: PMC6695584

Van Steenwinckel J, Schang AL, Krishnan ML, Sigaut S, Montané A, Verdonk F, Degos V, Hennebert O, Lebon S, Schwendimann L, Le Charpentier T, Hassan-Abdi R, Ball G, Aljabar P, Saxena A, Holloway RK, Birchmeier W, Auvynet C, Miron V, Rowitch D, Chretien F, Leconte C, Besson VC, Petretto EG, Edwards AD, Hagberg H, Soussi-Yanicostas N, Fleiss B, Gressens P. Loss of the Wnt pathway in microglia drives pro-inflammatory activation leading to white matter injury. Brain. 2019 Dec; 142(12): 3806-33. PMID: 31665242; PMCID: PMC6906599

Fréchou M, Margaill I, Marchand-Leroux C, Beray-Berthat V. Behavioral tests that reveal long-term deficits after permanent focal cerebral ischemia in mouse. Behav Brain Res. 2019 Mar 15;360:69-80. doi: 10.1016/j.bbr.2018.11.040. PMID: 30500429.

Pechmajou L et al. Paris-Sudden Death Expertise Center Investigators†. Impact of Coronary Lesion Stability on the Benefit of Emergent Percutaneous Coronary Intervention After Sudden Cardiac Arrest. Circ Cardiovasc Interv. 2020 Sep;13(9):e009181. doi: 10.1161/CIRCINTERVENTIONS.119.009181. Epub 2020 Sep 8. PMID: 32895006.

Schicchi A, Besson H, Rasamison R, Berleur MP, Mégarbane B. Fomepizole to treat disulfiram-ethanol reaction: a case series. Clin Toxicol (Phila). 2020 Sep;58(9):922-925. doi: 10.1080/15563650.2019.1708091. Epub 2019 Dec 26. PMID: 31878796.

Guillon A, Preau S, Aboab J, Azabou E, Jung B, Silva S, Textoris J, Uhel F, Vodovar D, Zafrani L, de Prost N, Radermacher P; Translational Research Committee of the French Intensive Care Society (Société de Réanimation de Langue Française). Preclinical septic shock research: why we need an animal ICU. Ann Intensive Care. 2019 Jun 10;9(1):66. doi: 10.1186/s13613-019-0543-6. PMID: 31183570; PMCID: PMC6557957.

Dufayet L, Galletto Pregliasco A, Meng P, Gilleron P, Vodovar D. Une intoxication professionnelle inhabituelle [Unusual occupational poisoning]. Rev Med Interne. 2020 Mar;41(3):216-217. French. doi: 10.1016/j.revmed.2019.05.008. Epub 2019 May 30. PMID: 31153650.

Langrand J, Dufayet L, Dridi I, Lagrange F, Leture N, Lopes De Oliveira T, Sagnelonge F, Vergondy F, Mazaud C, Laborde-Casterot H, Vodovar D. Comment on "poison control centers and alternative forms of communicating with the public": short messaging service (SMS) might also be useful for follow-up with patients who have contacted poison control centers. Clin Toxicol (Phila). 2019 Dec;57(12):1159-1160. doi: 10.1080/15563650.2019.1586915. Epub 2019 Mar 11. PMID: 30856007.

Labadie M, Rebouissoux L, Viala J, Nisse P, Vodovar D, Courtois A, Gallart JC, Glaizal M, Denoyelle F, Franchitto N, Manel J, Lamireau T, Puskarczyk E. Regarding pH-neutralizing esophageal irrigations as a novel mitigation strategy for button battery injury. Laryngoscope. 2019 Apr;129(4):E123-E124. doi: 10.1002/lary.27728. Epub 2019 Jan 7. PMID: 30618049.

Gouda AS, Khattab AM, Mégarbane B. Lessons from a methanol poisoning outbreak in Egypt: Six case reports. World J Crit Care Med. 2020 Aug 7;9(3):54-62. doi: 10.5492/wjccm.v9.i3.54. PMID: 32844091; PMCID: PMC7416361.

Mégarbane B, Tadayoni R. Cluster of chalazia in nurses using eye protection while caring for critically ill patients with COVID-19 in intensive care. Occup Environ Med. 2020 Aug;77(8):584-585. doi: 10.1136/oemed-2020-106677. Epub 2020 May 28. PMID: 32467314.

Mégarbane B, Weinberg GL. Hypotension and status epilepticus in relation to intrathecal morphine administration. Am J Emerg Med. 2020 Aug;38(8):1682-1683. doi: 10.1016/j.ajem.2020.03.065. Epub 2020 Apr 3. PMID: 32278571.

Caré W, Langrand J, Vodovar D, Deveaux M, Alvarez JC, Mégarbane B, Dorandeu F. Trends in severe opioid-related poisonings and fatalities reported to the Paris poison control center - a 10-year retrospective observational study. Fundam Clin Pharmacol. 2020 Aug;34(4):495-503. doi: 10.1111/fcp.12534. Epub 2020 Jan 29. PMID: 31945200.

Mégarbane B, Malissin I, Deye N, Voicu S. Topical Capsaicin To Treat Cannabinoid Hyperemesis Syndrome: Mind The Dose. Clin Toxicol (Phila). 2020 Aug;58(8):855-856. doi: 10.1080/15563650.2019.1694683. Epub 2019 Nov 25. PMID: 31760810.

Voicu S, Bonnin P, Stépanian A, Chousterman BG, Le Gall A, Malissin I, Deye N, Siguret V, Mebazaa A, Mégarbane B. High Prevalence of Deep Vein Thrombosis in Mechanically Ventilated COVID-19 Patients. J Am Coll Cardiol. 2020 Jul 28;76(4):480-482. doi: 10.1016/j.jacc.2020.05.053. Epub 2020 May 30. PMID: 32479784; PMCID: PMC7260513.

Watson JA, Tarning J, Hoglund RM, Baud FJ, Megarbane B, Clemessy JL, White NJ. Concentration-dependent mortality of chloroquine in overdose. Elife. 2020 Jul 8;9:e58631. doi: 10.7554/eLife.58631. PMID: 32639233; PMCID: PMC7417172.

Legrand M et al. I-MICRO trial investigators. The I-MICRO trial, Ilomedin for treatment of septic shock with persistent microperfusion defects: a double- blind, randomized controlled trial-study protocol for a randomized controlled trial. Trials. 2020 Jul 1;21(1):601. doi: 10.1186/s13063-020-04549-y. PMID: 32611377; PMCID: PMC7329442.

Mégarbane B, Scherrmann JM. Hydroxychloroquine and Azithromycin to Treat Patients With COVID-19: Both Friends and Foes? J Clin Pharmacol. 2020 Jul;60(7):808-814. doi: 10.1002/jcph.1646. Epub 2020 May 20. PMID: 32434282; PMCID: PMC7280673.

Rasamison R, Besson H, Berleur MP, Schicchi A, Mégarbane B. Analysis of fomepizole safety based on a 16-year post-marketing experience in France. Clin Toxicol (Phila). 2020 Jul;58(7):742-747. doi: 10.1080/15563650.2019.1676899. Epub 2019 Oct 14. PMID: 31608703.

Deye N, Voicu S, Megarbane B. Targeted Temperature Management for Cardiac Arrest. N Engl J Med. 2020 Jun 25;382(26):e109. doi: 10.1056/NEJMc2011066. PMID: 32579838.

Lautrette A, Boyer A, Gruson D, Argaud L, Schwebel C, Tardy B, Vignon P, Megarbane B, Schoeffler P, Chabrot P, Schmidt J, Boirie Y, Guerin C, Darmon M, Klouche K, Souweine B, Dellamonica J, Pereira B; TREX group. Impact of take-home messages written into slide presentations delivered during lectures on the retention of messages and the residents' knowledge: a randomized controlled study. BMC Med Educ. 2020 Jun 3;20(1):180. doi: 10.1186/s12909-020-02092-7. PMID: 32493318; PMCID: PMC7271544.

Alanio A, Dellière S, Fodil S, Bretagne S, Mégarbane B. Prevalence of putative invasive pulmonary aspergillosis in critically ill patients with COVID-19. Lancet Respir Med. 2020 Jun;8(6):e48-e49. doi: 10.1016/S2213-2600(20)30237-X. Epub 2020 May 20. PMID: 32445626; PMCID: PMC7239617.

Bougouin W et al. Sudden Death Expertise Center investigators. Extracorporeal cardiopulmonary resuscitation in out-of-hospital cardiac arrest: a registry study. Eur Heart J. 2020 Jun 1;41(21):1961-1971. doi: 10.1093/eurheartj/ehz753. PMID: 31670793.

Mégarbane B, Chevillard L, Vodovar D. Naloxone should remain the appropriate antidote to treat opioid overdose. Crit Care. 2020 Apr 28;24(1):173. doi: 10.1186/s13054-020-2835-5. PMID: 32345310; PMCID: PMC7187523.

Mégarbane B, Hassanian-Moghaddam H. Is fomepizole the antidote to recommend in mass methanol outbreaks? Clin Toxicol (Phila). 2020 Jun;58(6):504. doi: 10.1080/15563650.2019.1682152. Epub 2019 Oct 30. PMID: 31663389.

Vahabzadeh M, Mégarbane B. Abdominal pain related to adulterated opium: An emerging issue in drug addicts. World J Psychiatry. 2020 May 19;10(5):95-100. doi: 10.5498/wjp.v10.i5.95. PMID: 32477905; PMCID: PMC7243618.

Resiere D, Kallel H, Oxybel O, Chabartier C, Florentin J, Brouste Y, Gueye P, Megarbane B, Mehdaoui H. Clinical and Epidemiological Characteristics of Severe Acute Adult Poisoning Cases in Martinique: Implicated Toxic Exposures and Their Outcomes. Toxics. 2020 Apr 9;8(2):28. doi: 10.3390/toxics8020028. PMID: 32283693; PMCID: PMC7356022.

Sonneville R et al. SPICE investigators. Outcomes of Acute Stroke Patients Requiring Mechanical Ventilation: Study Protocol for the SPICE Multicenter Prospective Observational Study. Neurocrit Care. 2020 Apr;32(2):624-629. doi: 10.1007/s12028-019-00907-0. PMID: 32026446.

2019

Houzé MH, Deye N, Mateo J, Mégarbane B, Bizouard F, Baud FJ, Payen de la Garanderie D, Vicaut E, Yelnik AP; EVAKIN Study Group. Predictors of Extubation Failure Related to Aspiration and/or Excessive Upper Airway Secretions. Respir Care. 2020 Apr;65(4):475-481. doi: 10.4187/respcare.07025. Epub 2019 Nov 19. PMID: 31744867.

Leclercq M, Soichot M, Delhotal-Landes B, Bourgogne E, Gourlain H, Mégarbane B, Labat L. False positive amphetamines and 3,4-methylenedioxymethamphetamine immunoassays in the presence of metoprolol-two cases reported in clinical toxicology. J Anal Toxicol. 2020 Mar 7;44(2):200-205. doi: 10.1093/jat/bkz051. PMID: 31384953.

Vodovar D, Beaune S, Langrand J, Vicaut E, Labat L, Mégarbane B. Assessment of Extracorporeal Treatments in Poisoning criteria for the decision of extracorporeal toxin removal in lithium poisoning. Br J Clin Pharmacol. 2020 Mar;86(3):560-568. doi: 10.1111/bcp.14087. Epub 2019 Aug 30. PMID: 31378954; PMCID: PMC7080620.

Blet A et al. Adrenoss-1 study investigators. Added value of serial bio-adrenomedullin measurement in addition to lactate for the prognosis of septic patients admitted to ICU. Crit Care. 2020 Feb 28;24(1):69. doi: 10.1186/s13054-020-2794-x. PMID: 32111263; PMCID: PMC7048063.

Contou D et al. HOPEFUL Study Group. Pneumococcal purpura fulminans in asplenic or hyposplenic patients: a French multicenter exposed-unexposed retrospective cohort study. Crit Care. 2020 Feb 26;24(1):68. doi: 10.1186/s13054-020-2769-y. PMID: 32102696; PMCID: PMC7045371.

Martin M et al. Intubation Practices Survey Group. Nationwide survey on training and device utilization during tracheal intubation in French intensive care units. Ann Intensive Care. 2020 Jan 3;10(1):2. doi: 10.1186/s13613-019-0621-9. PMID: 31900637; PMCID: PMC6942097.

Cohier C, Salle S, Fontova A, Mégarbane B, Roussel O. Determination of buprenorphine, naloxone and phase I and phase II metabolites in rat whole blood by LC-MS/MS. J Pharm Biomed Anal. 2020 Feb 20;180:113042. doi: 10.1016/j.jpba.2019.113042. Epub 2019 Dec 16. PMID: 31865207.

Waldmann V, Karam N, Rischard J, Bougouin W, Sharifzadehgan A, Dumas F, Narayanan K, Sideris G, Voicu S, Gandjbakhch E, Jost D, Lamhaut L, Ludes B, Plu I, Beganton F, Wahbi K, Varenne O, Megarbane B, Algalarrondo V, Extramiana F, Lellouche N, Celermajer DS, Spaulding C, Lafont A, Cariou A, Jouven X, Marijon E; On Behalf Paris-SDEC investigators. Low rates of immediate coronary angiography among young adults resuscitated from sudden cardiac arrest. Resuscitation. 2020 Feb 1;147:34-42. doi: 10.1016/j.resuscitation.2019.12.005. Epub 2019 Dec 16. PMID: 31857140.

Gholamnezhad Z, Mégarbane B, Rezaee R. Molecular Mechanisms Mediating Adaptation to Exercise. Adv Exp Med Biol. 2020;1228:45-61. doi: 10.1007/978-981-15-1792-1_3. PMID: 32342449.

Bourcier S et al.Thyroid Storm in the ICU: A Retrospective Multicenter Study. Crit Care Med. 2020 Jan;48(1):83-90. doi: 10.1097/CCM.0000000000004078. PMID: 31714398.

Kimmoun A, Cariou A, Gayat E, Feliot E, Takagi K, Megarbane B, Mebazaa A, Deye N; FROG-ICU Study investigators. One-year outcome of patients admitted after cardiac arrest compared to other causes of ICU admission. An ancillary analysis of the observational prospective and multicentric FROG-ICU study. Resuscitation. 2020 Jan 1;146:237-246. doi: 10.1016/j.resuscitation.2019.10.021. Epub 2019 Oct 31. PMID: 31678408.

Resiere D, Mehdaoui H, Névière R, Olive C, Severyns M, Beaudoin A, Florentin J, Brouste Y, Banydeen R, Cabié A, Mégarbane B, Gutiérrez JM, Kallel H. Infectious Complications Following Snakebite by Bothrops lanceolatus in Martinique: A Case Series. Am J Trop Med Hyg. 2020 Jan;102(1):232-240. doi: 10.4269/ajtmh.19-0369. PMID: 31628740; PMCID: PMC6947800.

Pitasi CL, Liu J, Gausserès B, Pommier G, Delangre E, Armanet M, Cattan P, Mégarbane B, Hanak AS, Maouche K, Bailbé D, Portha B, Movassat J. Implication of glycogen synthase kinase 3 in diabetes-associated islet inflammation. J Endocrinol. 2020 Jan 1;244(1):133-148. doi: 10.1530/JOE-19-0239. PMID: 31600727.

Coppry M, Leroyer C, Saly M, Venier AG, Slekovec C, Bertrand X, Parer S, Alfandari S, Cambau E, Megarbane B, Lawrence C, Clair B, Lepape A, Cassier P, Trivier D, Boyer A, Boulestreau H, Asselineau J, Dubois V, Thiébaut R, Rogues AM. Exogenous acquisition of Pseudomonas aeruginosa in intensive care units: a prospective multi-centre study (DYNAPYO study). J Hosp Infect. 2020 Jan;104(1):40-45. doi: 10.1016/j.jhin.2019.08.008. Epub 2019 Aug 13. PMID: 31419468.

Martin E, Narjoz C, Decleves X, Labat L, Lambert C, Loriot MA, Ducheix G, Dualé C, Pereira B, Pickering G. Dextromethorphan Analgesia in a Human Experimental Model of Hyperalgesia. Anesthesiology. 2019 Aug;131(2):356-368. doi: 10.1097/ALN.0000000000002736. PMID: 31094746.

Basilua JM, Sawoo O, Mangin I, Dossou-Yovo F, Boussard A, Chevillard L, Lutete GT, Eto B, Peytavin G, Pochart P. Higher Atazanavir Plasma Exposure in Rats is Associated with Gut Microbiota Changes Induced by Cotrimoxazole. Curr Drug Metab. 2019;20(11):898-906. doi: 10.2174/1389200220666191023105609. PMID: 31702484.

Allard M, Puszkiel A, Conti F, Chevillard L, Kamar N, Noé G, White-Koning M, Thomas-Schoemann A, Simon T, Vidal M, Calmus Y, Blanchet B. Pharmacokinetics and Pharmacodynamics of Once-daily Prolonged-release Tacrolimus in Liver Transplant Recipients. Clin Ther. 2019 May;41(5):882-896.e3. doi: 10.1016/j.clinthera.2019.03.006. Epub 2019 Apr 17. PMID: 31003735.

Mégarbane B, Catherine L, Soichot M, Labat L. Enhanced toxicity from powder cocaine use in comparison to crack cocaine use - an observational study in the intensive care unit. Clin Toxicol (Phila). 2020 Jan;58(1):71-72. doi: 10.1080/15563650.2019.1596281. Epub 2019 Apr 3. PMID: 30942637.

Zerdazi EH, Vorspan F, Marees AT, Naccache F, Lepine JP, Laplanche JL, Prince N, Marie-Claire C, Bellivier F, Mouly S, Bloch V. QT length during methadone maintenance treatment: gene × dose interaction. Fundam Clin Pharmacol. 2019 Feb;33(1):96-106. doi: 10.1111/fcp.12405. PMID: 30086202.

Dépret F, Hoffmann C, Daoud L, Thieffry C, Monplaisir L, Creveaux J, Annane D, Parmentier E, Mathieu D, Wiramus S, Demeure DIt Latte D, Kpodji A, Textoris J, Robin F, Klouche K, Pontis E, Schnell G, Barbier F, Constantin JM, Clavier T, du Cheyron D, Terzi N, Sauneuf B, Guerot E, Lafon T, Herbland A, Megarbane B, Leclerc T, Mallet V, Pirracchio R, Legrand M. Association between hydroxocobalamin administration and acute kidney injury after smoke inhalation: a multicenter retrospective study. Crit Care. 2019 Dec 23;23(1):421. doi: 10.1186/s13054-019-2706-0. PMID: 31870461; PMCID: PMC6929494.

Resiere D, Valentino R, Nevière R, Banydeen R, Gueye P, Florentin J, Cabié A, Lebrun T, Mégarbane B, Guerrier G, Mehdaoui H. Sargassum seaweed on Caribbean islands: an international public health concern. Lancet. 2019 Dec 22;392(10165):2691. doi: 10.1016/S0140-6736(18)32777-6. PMID: 30587359.

Lascarrou JB et al. SDEC. Temporal trends in the use of targeted temperature management after cardiac arrest and association with outcome: insights from the Paris Sudden Death Expertise Centre. Crit Care. 2019 Dec 3;23(1):391. doi: 10.1186/s13054-019-2677-1. PMID: 31796127; PMCID: PMC6892202.

Martin-Loeches I et al. TAVeM study Group. The association of cardiovascular failure with treatment for ventilator-associated lower respiratory tract infection. Intensive Care Med. 2019 Dec;45(12):1753-1762. doi: 10.1007/s00134-019-05797-6. Epub 2019 Oct 16. PMID: 31620836.

Hassanian-Moghaddam H, Zamani N, Roberts DM, Brent J, McMartin K, Aaron C, Eddleston M, Dargan PI, Olson K, Nelson L, Bhalla A, Hantson P, Jacobsen D, Megarbane B, Balali-Mood M, Buckley NA, Zakharov S, Paasma R, Jarwani B, Mirafzal A, Salek T, Hovda KE. Consensus statements on the approach to patients in a methanol poisoning outbreak. Clin Toxicol (Phila). 2019 Dec;57(12):1129-1136. doi: 10.1080/15563650.2019.1636992. Epub 2019 Jul 22. PMID: 31328583.

Mégarbane B, Gouda AS, El-Nabarawy NA. Understanding the risk of seizure in tramadol overdose: still a long way to go. Clin Toxicol (Phila). 2019 Dec;57(12):1161-1162. doi: 10.1080/15563650.2019.1591433. Epub 2019 Mar 20. PMID: 30892953.

Laterre PF et al. SEPSIS-ACT Investigators. Effect of Selepressin vs Placebo on Ventilator- and Vasopressor-Free Days in Patients With Septic Shock: The SEPSIS-ACT Randomized Clinical Trial. JAMA. 2019 Oct 15;322(15):1476-1485. doi: 10.1001/jama.2019.14607. Erratum in: JAMA. 2019 Nov 12;322(18):1830. PMID: 31577035; PMCID: PMC6802260.

Galicia M et al. Euro-DEN Plus Research Group. Clinical relevance of ethanol coingestion in patients with GHB/GBL intoxication. Toxicol Lett. 2019 Oct 10;314:37-42. doi: 10.1016/j.toxlet.2019.07.001. Epub 2019 Jul 10. PMID: 31301370.

Mégarbane B. Carbon monoxide intoxication in the 21st century: the battle to improve outcomes continues. Emergencias. 2019 Oct;31(5):300-301. Spanish, English. PMID: 31625299.

Contou D, Sonneville R, Mekontso Dessap A, de Prost N; HOPEFUL study group. Diagnostic yield of lumbar puncture in adult patients with purpura fulminans. Intensive Care Med. 2019 Oct;45(10):1487-1489. doi: 10.1007/s00134-019-05676-0. Epub 2019 Jul 5. PMID: 31278443.

Laurent A et al. "You helped me keep my head above water"-experience of bereavement research after loss of a loved one in the ICU: insights from the ARREVE study. Intensive Care Med. 2019 Sep;45(9):1252-1261. doi: 10.1007/s00134-019-05722-x. Epub 2019 Aug 12. PMID: 31407041.

Calabró L, Bougouin W, Cariou A, De Fazio C, Skrifvars M, Soreide E, Creteur J, Kirkegaard H, Legriel S, Lascarrou JB, Megarbane B, Deye N, Taccone FS. Effect of different methods of cooling for targeted temperature management on outcome after cardiac arrest: a systematic review and meta-analysis. Crit Care. 2019 Aug 23;23(1):285. doi: 10.1186/s13054-019-2567-6. PMID: 31443696; PMCID: PMC6708171.

Augy JL, Aissaoui N, Richard C, Maury E, Fartoukh M, Mekontso-Dessap A, Paulet R, Anguel N, Blayau C, Cohen Y, Chiche JD, Gaudry S, Voicu S, Demoule A, Combes A, Megarbane B, Charpentier E, Haghighat S, Panczer M, Diehl JL. A 2-year multicenter, observational, prospective, cohort study on extracorporeal CO₂ removal in a large metropolis area. J Intensive Care. 2019 Aug 20;7:45. doi: 10.1186/s40560-019-0399-8. PMID: 31452899; PMCID: PMC6701003.

Balmier A, Dib F, Serret-Larmande A, De Montmollin E, Pouyet V, Sztrymf B, Megarbane B, Thiagarajah A, Dreyfuss D, Ricard JD, Roux D. Initial management of diabetic ketoacidosis and prognosis according to diabetes type: a French multicentre observational retrospective study. Ann Intensive Care. 2019 Aug 15;9(1):91. doi: 10.1186/s13613-019-0567-y. PMID: 31418117; PMCID: PMC6695456.

Miró Ò et al. Euro-DEN Plus Research Group; Galicia M. Epidemiology, clinical features and management of patients presenting to European emergency departments with acute cocaine toxicity: comparison between powder cocaine and crack cocaine cases. Clin Toxicol (Phila). 2019 Aug;57(8):718-726. doi: 10.1080/15563650.2018.1549735. Epub 2019 Jan 30. PMID: 30696283.

Contou D et al. Hopeful Study Group. Long-term Quality of Life in Adult Patients Surviving Purpura Fulminans: An Exposed-Unexposed Multicenter Cohort Study. Clin Infect Dis. 2019 Jul 2;69(2):332-340. doi: 10.1093/cid/ciy901. PMID: 30335142.

Wolfe CE et al. Euro-DEN Research Group. Seizures as a complication of recreational drug use: Analysis of the Euro-DEN Plus data-set. Neurotoxicology. 2019 Jul;73:183-187. doi: 10.1016/j.neuro.2019.04.003. Epub 2019 Apr 8. PMID: 30974132.

Resiere D, Mehdaoui H, Névière R, Mégarbane B. Sargassum invasion in the Caribbean: the role of medical and scientific cooperation. Rev Panam Salud Publica. 2019 Jun 7;43:e52. doi: 10.26633/RPSP.2019.52. PMID: 31171924; PMCID: PMC6548073.

Ghazanfarpour M, Najafi MN, Roozbeh N, Mashhadi ME, Keramat-Roudi A, Mégarbane B, Tsatsakis A, Moghaddam MMM, Rezaee R. Therapeutic approaches for neonatal abstinence syndrome: a systematic review of randomized clinical trials. Daru. 2019 Jun;27(1):423-431. doi: 10.1007/s40199-019-00266-3. Epub 2019 May 15. PMID: 31093953; PMCID: PMC6593026.

Vodovar D, Langrand J, Tournier N, Mégarbane B. La crise des overdoses américaines : une menace pour la France ? [The American opioid overdose crisis: A threat for France?]. Rev Med Interne. 2019 Jun;40(6):389-394. French. doi: 10.1016/j.revmed.2018.10.389. Epub 2018 Nov 11. PMID: 30429046.

Jouan Y, Seegers V, Meziani F, Grelon F, Megarbane B, Anguel N, Mira JP, Dequin PF, Gergaud S, Weiss N, Legay F, Le Tulzo Y, Conrad M, Robert R, Gonzalez F, Guitton C, Tamion F, Tonnelier JM, Guezennec P, Van Der Linden T, Vieillard- Baron A, Radermacher P, Asfar P. Effects of mean arterial pressure on arousal in sedated ventilated patients with septic shock: a SEPSISPAM post hoc exploratory study. Ann Intensive Care. 2019 May 9;9(1):54. doi: 10.1186/s13613-019-0528-5. PMID: 31073873; PMCID: PMC6509319.

Shahin NN, El-Nabarawy NA, Gouda AS, Mégarbane B. The protective role of spermine against male reproductive aberrations induced by exposure to electromagnetic field - An experimental investigation in the rat. Toxicol Appl Pharmacol. 2019 May 1;370:117-130. doi: 10.1016/j.taap.2019.03.009. Epub 2019 Mar 13. PMID: 30878504.

Joffre J et al. CUB-Réa Network. Epidemiology of infective endocarditis in French intensive care units over the 1997-2014 period-from CUB- Réa Network. Crit Care. 2019 Apr 25;23(1):143. doi: 10.1186/s13054-019-2387-8. PMID: 31027489; PMCID: PMC6485099.

Oddo M, Bracard S, Cariou A, Chanques G, Citerio G, Clerckx B, Godeau B, Godier A, Horn J, Jaber S, Jung B, Kuteifan K, Leone M, Mailles A, Mazighi M, Mégarbane B, Outin H, Puybasset L, Sharshar T, Sandroni C, Sonneville R, Weiss N, Taccone FS. Update in Neurocritical Care: a summary of the 2018 Paris international conference of the French Society of Intensive Care. Ann Intensive Care. 2019 Apr 16;9(1):47. doi: 10.1186/s13613-019-0523-x. PMID: 30993550; PMCID: PMC6468018.

Bouglé A, Le Gall A, Dumas F, Geri G, Malissin I, Voicu S, Mégarbane B, Cariou A, Deye N. ExtraCorporeal life support for Cardiac ARrest in patients with post cardiac arrest syndrome: The ECCAR study. Arch Cardiovasc Dis. 2019 Apr;112(4):253-260. doi: 10.1016/j.acvd.2018.11.005. Epub 2019 Jan 3. PMID: 30612896.

Atehortua-Martinez LA, Masniere C, Campolongo P, Chasseigneaux S, Callebert J, Zwergel C, Mai A, Laplanche JL, Chen H, Etheve-Quelquejeu M, Mégarbane B, Benturquia N. Acute and chronic neurobehavioral effects of the designer drug and bath salt constituent 3,4-methylenedioxypyrovalerone in the rat. J Psychopharmacol. 2019 Mar;33(3):392-405. doi: 10.1177/0269881118822151. Epub 2019 Jan 15. PMID: 30644332.

Vodovar D, Mégarbane B. Seizures induced by tramadol overdose: what is the respective contribution of tramadol and each of its metabolites? Drug Metab Pers Ther. 2019 Feb 28;34(1). doi: 10.1515/dmpt-2018-0025. PMID: 30817297.

Garnier M et al. BLUE-CarbA study group.. Multicentre randomised controlled trial to investigate usefulness of the rapid diagnostic βLACTA test performed directly on bacterial cell pellets from respiratory, urinary or blood samples for the early de-escalation of carbapenems in septic intensive care unit patients: the BLUE-CarbA protocol. BMJ Open. 2019 Feb 19;9(2):e024561. doi: 10.1136/bmjopen-2018-024561. PMID: 30782909; PMCID: PMC6367973.

Huynh Tuong A, Despréaux T, Loeb T, Salomon J, Mégarbane B, Descatha A. Emergency management of chlorine gas exposure - a systematic review. Clin Toxicol (Phila). 2019 Feb;57(2):77-98. doi: 10.1080/15563650.2018.1519193. Epub 2019 Jan 23. PMID: 30672349.

Jurek L, Nourredine M, Megarbane B, d'Amato T, Dorey JM, Rolland B. Le syndrome sérotoninergique : une revue actualisée de la littérature [The serotonin syndrome: An updated literature review]. Rev Med Interne. 2019 Feb;40(2):98-104. French. doi: 10.1016/j.revmed.2018.08.010. Epub 2018 Sep 20. PMID: 30243558.

Mégarbane B, Villa A. Poisoning with Ethanol and 2-Propanol-Based Hand Rubs: Give Caesar What Belongs to Caesar! Neurocrit Care. 2019 Feb;30(1):226-228. doi: 10.1007/s12028-010-9353-2. PMID: 20369306.

Tavassoli M, Afshari A, Arsene AL, Mégarbane B, Dumanov J, Paoliello MMB, Tsatsakis A, Carvalho F, Hashemzaei M, Karimi G, Rezaee R. Toxicological profile of Amanita virosa - A narrative review. Toxicol Rep. 2019 Jan 9;6:143-150. doi: 10.1016/j.toxrep.2019.01.002. PMID: 30705830; PMCID: PMC6348736.

Resiere D, Mehdaoui H, Megarbane B. Cardiac Arrest in the Airport Revealing Cocaine Body Packing: A Case Report. Case Rep Med. 2019 Jan 6;2019:6183154. doi: 10.1155/2019/6183154. PMID: 30723506; PMCID: PMC6339722.

2018

Nuzzo A, Shaar-Chneker C, Maillet M, Mégarbane B. Gastroduodenal injury induced by orally administered sodium polystyrene sulfonate. Clin Toxicol (Phila). 2019 Jan;57(1):75-76. doi: 10.1080/15563650.2018.1518529. Epub 2018 Oct 11. PMID: 30307337.

Nuzzo A, Dautry R, Francoz C, Logeart D, Mégarbane B. Hepatopulmonary syndrome-attributed extreme hypoxemia and polycythemia revealing liver cirrhosis. Am J Emerg Med. 2019 Jan;37(1):175.e1-175.e2. doi: 10.1016/j.ajem.2018.09.044. Epub 2018 Sep 26. PMID: 30269997.

Lyphout C et al. Euro-DEN Research Group; Wood DM. Presentations to the emergency department with non-medical use of benzodiazepines and Z-drugs: profiling and relation to sales data. Eur J Clin Pharmacol. 2019 Jan;75(1):77-85. doi: 10.1007/s00228-018-2550-1. Epub 2018 Sep 22. PMID: 30244371.

Yamamoto T et al. Euro-DEN Research Group. Concurrent Use of Benzodiazepine by Heroin Users-What Are the Prevalence and the Risks Associated with This Pattern of Use? J Med Toxicol. 2019 Jan;15(1):4-11. doi: 10.1007/s13181-018-0674-4. Epub 2018 Jul 31. PMID: 30066312; PMCID: PMC6314928.

Mebazaa A et al. AdrenOSS-1 study investigators. Circulating adrenomedullin estimates survival and reversibility of organ failure in sepsis: the prospective observational multinational Adrenomedullin and Outcome in Sepsis and Septic Shock-1 (AdrenOSS-1) study. Crit Care. 2018 Dec 21;22(1):354. doi: 10.1186/s13054-018-2243-2. PMID: 30583748; PMCID: PMC6305573.

Lefevre T, Nuzzo A, Mégarbane B. Poppers-induced Life-Threatening Methemoglobinemia. Am J Respir Crit Care Med. 2018 Dec 15;198(12):e137-e138. doi: 10.1164/rccm.201806-1044IM. PMID: 30113866; PMCID: PMC7212794.

Vodovar D, Duchêne A, Wimberley C, Leroy C, Pottier G, Dauvilliers Y, Giaume C, Lin JS, Mouthon F, Tournier N, Charvériat M. Cortico-Amygdala-Striatal Activation by Modafinil/Flecainide Combination. Int J Neuropsychopharmacol. 2018 Jul 1;21(7):687-696. doi: 10.1093/ijnp/pyy027. PMID: 29635319; PMCID: PMC6031015.

Icick R, Vorspan F, Karsinti E, Ksouda K, Lépine JP, Brousse G, Mouly S, Bellivier F, Bloch V. Gender-specific study of recurrent suicide attempts in outpatients with multiple substance use disorders. J Affect Disord. 2018 Dec 1;241:546-553. doi: 10.1016/j.jad.2018.08.076. Epub 2018 Aug 13. PMID: 30153638.

Vodovar D, Thomas L, Mongardon N, Lepeule R, Lebrun-Vignes B, Biour M, Netzer F, Haouache H, Le Beller C, Dhonneur G. Dramatic Increase of Amoxicillin- Induced Crystal Nephropathy Found in a Cohort Study of French Pharmacovigilance Centers. Antimicrob Agents Chemother. 2018 Feb 23;62(3):e01630-17. doi: 10.1128/AAC.01630-17. PMID: 29263078; PMCID: PMC5826165.

Bedos JP, Varon E, Porcher R, Asfar P, Le Tulzo Y, Megarbane B, Mathonnet A, Dugard A, Veinstein A, Ouchenir K, Siami S, Reignier J, Galbois A, Cousson J, Preau S, Baldesi O, Rigaud JP, Souweine B, Misset B, Jacobs F, Dewavrin F, Mira JP. Host-pathogen interactions and prognosis of critically ill immunocompetent patients with pneumococcal pneumonia: the nationwide prospective observational STREPTOGENE study. Intensive Care Med. 2018 Dec;44(12):2162-2173. doi: 10.1007/s00134-018-5444-x. Epub 2018 Nov 19. PMID: 30456466.

Vodovar D, Megarbane B. Ephenidine, diphenidine and methoxphenidine complications reported to the French Addictovigilance Network: another brick in the wall! Fundam Clin Pharmacol. 2018 Dec;32(6):652-653. doi: 10.1111/fcp.12407. PMID: 30417492.

Mégarbane B, Lagard C, Chevillard L. Tramadol: Distinguishing the Pathophysiology of Serotonin Syndrome and Seizures. Am J Med. 2018 Nov;131(11):e487. doi: 10.1016/j.amjmed.2018.07.005. Epub 2018 Oct 26. PMID: 30392647.

Rashid EAMA, El-Mahdy NM, Kharoub HS, Gouda AS, ElNabarawy NA, Mégarbane B. Iatrogenic Botulism Outbreak in Egypt due to a Counterfeit Botulinum Toxin A Preparation - A Descriptive Series of Patient Features and Outcome. Basic Clin Pharmacol Toxicol. 2018 Nov;123(5):622-627. doi: 10.1111/bcpt.13048. Epub 2018 Jun 21. PMID: 29786953.

Karimani A, Mohammadpour AH, Zirak MR, Rezaee R, Megarbane B, Tsatsakis A, Karimi G. Antidotes for aluminum phosphide poisoning - An update. Toxicol Rep. 2018 Oct 28;5:1053-1059. doi: 10.1016/j.toxrep.2018.10.009. PMID: 30406022; PMCID: PMC6214862.

Flechel A, Jolivet A, Boukhari R, Misslin-Tritsch C, Manca MF, Wiel E, Megarbane B, Pousset F. Paraquat poisoning in Western French Guyana: a public health problem persisting ten years after its withdrawal from the French market. Eur Rev Med Pharmacol Sci. 2018 Oct;22(20):7034-7038. doi: 10.26355/eurrev_201810_16175. PMID: 30402871.

Résière D, Olive C, Kallel H, Cabié A, Névière R, Mégarbane B, Gutiérrez JM, Mehdaoui H. Oral Microbiota of the Snake Bothrops lanceolatus in Martinique. Int J Environ Res Public Health. 2018 Sep 27;15(10):2122. doi: 10.3390/ijerph15102122. PMID: 30261677; PMCID: PMC6209983.

Kimmoun A, Oulehri W, Sonneville R, Grisot PH, Zogheib E, Amour J, Aissaoui N, Megarbane B, Mongardon N, Renou A, Schmidt M, Besnier E, Delmas C, Dessertaine G, Guidon C, Nesseler N, Labro G, Rozec B, Pierrot M, Helms J, Bougon D, Chardonnal L, Medard A, Ouattara A, Girerd N, Lamiral Z, Borie M, Ajzenberg N, Levy B. Prevalence and outcome of heparin-induced thrombocytopenia diagnosed under veno-arterial extracorporeal membrane oxygenation: a retrospective nationwide study. Intensive Care Med. 2018 Sep;44(9):1460-1469. doi: 10.1007/s00134-018-5346-y. Epub 2018 Aug 22. PMID: 30136139.

Berger N, Besson VC, Boulares H, Bürkle A, Chiarugi A, Clark RSB, Curtin N, Cuzzocrea S, Dawson T, Dawson V, Haskó G, Liaudet L, Moroni F, Pacher P, Radermacher P, Salzman A, Snyder SH, Soriano F, Strosznajder, R, Sumegi B, Swanson R, Szabo C. Opportunities for repurposing of poly(ADP-ribose) polymerase (PARP) inhibitors for the therapy of non-oncological diseases. Br J Pharmacol. 2018 Jan;175(2): 192-222. PMID: 28213892; PMCID: PMC5758399

El Amki M, Lerouet D, Garraud M, Teng F, Beray-Berthat V, Coqueran B, Barsacq B, Abbou C, Palmier B, Marchand-Leroux C, Margaill I. Improved Reperfusion and Vasculoprotection by the Poly(ADP-Ribose)Polymerase Inhibitor PJ34 After Stroke and Thrombolysis in Mice. Mol Neurobiol. 2018 Dec; 55: 9156-9168. PMID: 29651748

Charriaut-Marlangue C, Leconte C, Csaba Z, Talatizi M, Simon K, Baud O, Marchand-Leroux C, Besson VC. Sex differences in the effect of PARP inhibition on microglial phenotypes following neonatal stroke. Brain Behav Immun. 2018 Oct; 73: 375-89. PMID: 29852289

Contou D et al. Hopeful Study Group. Clinical spectrum and short-term outcome of adult patients with purpura fulminans: a French multicenter retrospective cohort study. Intensive Care Med. 2018 Sep;44(9):1502-1511. doi: 10.1007/s00134-018-5341-3. Epub 2018 Aug 20. PMID: 30128591.

Benturquia N, Chevillard L, Poiré C, Roussel O, Cohier C, Declèves X, Laplanche JL, Etheve-Quelquejeu M, Chen H, Mégarbane B. Is the 3,4-methylendioxypyrovalerone/mephedrone combination responsible for enhanced stimulant effects? A rat study with investigation of the effect/concentration relationships. Psychopharmacology (Berl). 2019 Mar;236(3):891-901. doi: 10.1007/s00213-018-4962-0. Epub 2018 Jul 3. PMID: 29971461.

Cantier M, Morisot A, Guérot E, Megarbane B, Razazi K, Contou D, Mariotte E, Canet E, De Montmollin E, Dubée V, Boulet E, Gaudry S, Voiriot G, Mayaux J, Pène F, Neuville M, Mourvillier B, Ruckly S, Bouadma L, Wolff M, Timsit JF, Sonneville R; ENCEPHALITICA study group. Functional outcomes in adults with tuberculous meningitis admitted to the ICU: a multicenter cohort study. Crit Care. 2018 Aug 17;22(1):210. doi: 10.1186/s13054-018-2140-8. PMID: 30119686; PMCID: PMC6098613.

Warembourg C, Binter AC, Giton F, Fiet J, Labat L, Monfort C, Chevrier C, Multigner L, Cordier S, Garlantézec R. Prenatal exposure to glycol ethers and sex steroid hormones at birth. Environ Int. 2018 Apr;113:66-73. doi:10.1016/j.envint.2018.01.013. Epub 2018 Feb 6. PMID: 29421409.

Valade S, Biard L, Lemiale V, Argaud L, Pène F, Papazian L, Bruneel F, Seguin A, Kouatchet A, Oziel J, Rouleau S, Bele N, Razazi K, Lesieur O, Boissier F, Megarbane B, Bigé N, Brulé N, Moreau AS, Lautrette A, Peyrony O, Perez P, Mayaux J, Azoulay E. Severe atypical pneumonia in critically ill patients: a retrospective multicenter study. Ann Intensive Care. 2018 Aug 13;8(1):81. doi: 10.1186/s13613-018-0429-z. PMID: 30105627; PMCID: PMC6089852.

Geri G et al. PREDICT investigators. Prediction of chronic kidney disease after acute kidney injury in ICU patients: study protocol for the PREDICT multicenter prospective observational study. Ann Intensive Care. 2018 Jul 6;8(1):77. doi: 10.1186/s13613-018-0421-7. PMID: 29980878; PMCID: PMC6035124.

Warembourg C, Botton J, Lelong N, Rouget F, Khoshnood B, Le Gléau F, Monfort C, Labat L, Pierre F, Heude B, Slama R, Multigner L, Charles MA, Cordier S, Garlantézec R. Prenatal exposure to glycol ethers and cryptorchidism and hypospadias: a nested case-control study. Occup Environ Med. 2018 Jan;75(1):59-65. doi: 10.1136/oemed-2017-104391. Epub 2017 Oct 21. PMID: 29055888.

Reis R, Labat L, Allard M, Boudou-Rouquette P, Chapron J, Bellesoeur A, Thomas-Schoemann A, Arrondeau J, Giraud F, Alexandre J, Vidal M, Goldwasser F, Blanchet B. Liquid chromatography-tandem mass spectrometric assay for therapeutic drug monitoring of the EGFR inhibitors afatinib, erlotinib and osimertinib, the ALK inhibitor crizotinib and the VEGFR inhibitor nintedanib in human plasma from non-small cell lung cancer patients. J Pharm Biomed Anal. 2018 Sep 5;158:174-183. doi: 10.1016/j.jpba.2018.05.052. Epub 2018 Jun 1. PMID: 29883880.

Voicu S, Megarbane B, Sideris G. Letter by Voicu et al Regarding Article, "Derivation and Validation of the CREST Model for Very Early Prediction of Circulatory Etiology Death in Patients Without ST-Segment-Elevation Myocardial Infarction After Cardiac Arrest". Circulation. 2018 Jul 3;138(1):118-119. doi: 10.1161/CIRCULATIONAHA.117.032873. PMID: 29967239.

Chartier M, Tannous S, Benturquia N, Labat L, Reis R, Risède P, Chevillard L, Mégarbane B. Baclofen-Induced Neuro-Respiratory Toxicity in the Rat: Contribution of Tolerance and Characterization of Withdrawal Syndrome. Toxicol Sci. 2018 Jul 1;164(1):153-165. doi: 10.1093/toxsci/kfy073. PMID: 29945230.

Chartier M, Malissin I, Tannous S, Labat L, Risède P, Mégarbane B, Chevillard L. Baclofen-induced encephalopathy in overdose - Modeling of the electroencephalographic effect/concentration relationships and contribution of tolerance in the rat. Prog Neuropsychopharmacol Biol Psychiatry. 2018 Aug 30;86:131-139. doi: 10.1016/j.pnpbp.2018.05.016. Epub 2018 May 18. PMID: 29782961.

Gaudry S, Hajage D, Schortgen F, Martin-Lefevre L, Verney C, Pons B, Boulet E, Boyer A, Chevrel G, Lerolle N, Carpentier D, de Prost N, Lautrette A, Bretagnol A, Mayaux J, Nseir S, Megarbane B, Thirion M, Forel JM, Maizel J, Yonis H, Markowicz P, Thiery G, Tubach F, Ricard JD, Dreyfuss D. Timing of Renal Support and Outcome of Septic Shock and Acute Respiratory Distress Syndrome. A Post Hoc Analysis of the AKIKI Randomized Clinical Trial. Am J Respir Crit Care Med. 2018 Jul 1;198(1):58-66. doi: 10.1164/rccm.201706-1255OC. PMID: 29351007.

Resiere D, Arias AS, Villalta M, Rucavado A, Brouste Y, Cabié A, Névière R, Césaire R, Kallel H, Mégarbane B, Mehdaoui H, Gutiérrez JM. Preclinical evaluation of the neutralizing ability of a monospecific antivenom for the treatment of envenomings by Bothrops lanceolatus in Martinique. Toxicon. 2018 Jun 15;148:50-55. doi: 10.1016/j.toxicon.2018.04.010. Epub 2018 Apr 12. PMID: 29654867.

Voicu S, Sideris G, Dillinger JG, Yannopoulos D, Deye N, Kang C, Bonneau M, Bartos J, Kedra A, Bailliart S, Pasteur-Rousseau A, Amah G, Bonnin P, Callebert J, Henry P, Megarbane B. Synchronized Pulsatile Flow With Low Systolic Output From Veno-Arterial Extracorporeal Membrane Oxygenation Improves Myocardial Recovery After Experimental Cardiac Arrest in Pigs. Artif Organs. 2018 Jun;42(6):597-604. doi: 10.1111/aor.13089. Epub 2018 Mar 6. PMID: 29508418.

Combes A et al. EOLIA Trial Group, REVA, and ECMONet. Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome. N Engl J Med. 2018 May 24;378(21):1965-1975. doi: 10.1056/NEJMoa1800385. PMID: 29791822.

Kallel H, Mayence C, Houcke S, Mathien C, Mehdaoui H, Gutiérrez JM, Megarbane B, Hommel D, Resiere D. Severe snakebite envenomation in French Guiana: When antivenom is not available. Toxicon. 2018 May;146:87-90. doi: 10.1016/j.toxicon.2018.04.004. Epub 2018 Apr 3. PMID: 29621529.

Kallel H, Hommel D, Mehdaoui H, Megarbane B, Resiere D. Snakebites in French Guiana: Conclusions of an international symposium. Toxicon. 2018 May;146:91-94. doi: 10.1016/j.toxicon.2018.04.003. Epub 2018 Apr 3. PMID: 29621524.

Hernu R et al. “Costs in French ICU” Study Group. Are nurses ready to help to improve cost-effectiveness? A multicentric national survey on knowledge of costs among ICU paramedical staff. Intensive Care Med. 2018 May;44(5):663-664. doi: 10.1007/s00134-017-5032-5. Epub 2017 Dec 26. PMID: 29279972.

Mégarbane B, Mehdaoui H, Résière D. Near-Drowning: To Be or Not to Be … Is It the Question? Int J Environ Res Public Health. 2018 Apr 15;15(4):760. doi: 10.3390/ijerph15040760. PMID: 29662046; PMCID: PMC5923802.

Moreau AS, Martin-Loeches I, Povoa P, Salluh J, Rodriguez A, Thille AW, Diaz Santos E, Vedes E, Lobo SM, Mégarbane B, Molero Silvero E, Coelho L, Argaud L, Sanchez Iniesta R, Labreuche J, Rouzé A, Nseir S; TAVeM Study Group. Impact of immunosuppression on incidence, aetiology and outcome of ventilator- associated lower respiratory tract infections. Eur Respir J. 2018 Mar 8;51(3):1701656. doi: 10.1183/13993003.01656-2017. PMID: 29439020.

Nuzzo A, Peron N, Voicu S, Mégarbane B, Deye N. Targeted temperature management for non-shockable cardiac arrests: the debate must go on. J Thorac Dis. 2018 Mar;10(3):1304-1307. doi: 10.21037/jtd.2018.03.32. PMID: 29707282; PMCID: PMC5906274.

Annane D, Renault A, Brun-Buisson C, Megarbane B, Quenot JP, Siami S, Cariou A, Forceville X, Schwebel C, Martin C, Timsit JF, Misset B, Ali Benali M, Colin G, Souweine B, Asehnoune K, Mercier E, Chimot L, Charpentier C, François B, Boulain T, Petitpas F, Constantin JM, Dhonneur G, Baudin F, Combes A, Bohé J, Loriferne JF, Amathieu R, Cook F, Slama M, Leroy O, Capellier G, Dargent A, Hissem T, Maxime V, Bellissant E; CRICS-TRIGGERSEP Network. Hydrocortisone plus Fludrocortisone for Adults with Septic Shock. N Engl J Med. 2018 Mar 1;378(9):809-818. doi: 10.1056/NEJMoa1705716. PMID: 29490185.

Resiere D, Hossein M, Megarbane B. Snake Bites by Bothrops lanceolatus in Martinique. Med Sante Trop. 2018 Feb 1;28(1):37-43. English. doi: 10.1684/mst.2018.0760. PMID: 29616641.

Miró Ò, Yates C, Dines AM, Wood DM, Dargan PI, Galán I, Jerez A, Puiguriguer J, Waring WS, Moughty A, O'Connor N, Heyerdahl F, Hovda KE, Vallersnes OM, Paasma R, Põld K, Jürgens G, Megarbane B, Anand JS, Liakoni E, Liechti M, Eyer F, Zacharov S, Caganova B, Giraudon I, Galicia M. Emergencies related to recreational drug abuse in Spain compared to emergencies attended in 3 European areas. Emergencias. 2018 Dic;30(6):385-394. English, Spanish. PMID: 30638341.

Voicu S, Henry P, Malissin I, Dillinger J-G, Koumoulidis A, Magkoutis N, Yannopoulos D, Logeart D, Manzo-Silberman S, Péron N, Deye N, Megarbane B, Sideris G. Improving cannulation time for extracorporeal life support in refractory cardiac arrest of presumed cardiac cause - Comparison of two percutaneous cannulation techniques in the catheterization laboratory in a center without on-site cardiovascular surgery. Resuscitation. 2018 Jan;122:69-75. doi: 10.1016/j.resuscitation.2017.11.057. Epub 2017 Nov 26. PMID: 29183830.

Resiere D, Fergé JL, Fabre J, Raad M, Aitsatou S, Inamo J, Cabié A, Megarbane B, Mehdaoui H. Cardiovascular complications in patients with Zika virus-induced Guillain-Barré syndrome. J Clin Virol. 2018 Jan;98:8-9. doi: 10.1016/j.jcv.2017.11.002. Epub 2017 Nov 10. PMID: 29175232.

Bruneel F, Tubach F, Mira JP, Houze S, Gibot S, Huisse MG, Megarbane B, Choquet C, Corne P, Peytel E, Villers D, Camus C, Bouchaud O, Caumes E, Girard PM, Simon F, Kalloumeh A, Roy C, Durand R, Le Bras J, Matheron S, Wolff M; PALUREA Study Group. Correction to: Imported falciparum malaria in adults: host- and parasite-related factors associated with severity. The French prospective multicenter PALUREA cohort study. Intensive Care Med. 2018 Jan;44(1):141-143. doi: 10.1007/s00134-017-4978-7. Erratum for: Intensive Care Med. 2016 Oct;42(10 ):1588-1596. PMID: 29138897.

2017

Robert R et al. Correction to: Terminal weaning or immediate extubation for withdrawing mechanical ventilation in critically ill patients (the ARREVE observational study). Intensive Care Med. 2017 Dec;43(12):1942-1943. doi: 10.1007/s00134-017-4999-2. Erratum for: Intensive Care Med. 2017 Dec;43(12 ):1793-1807. PMID: 29178042.

Chevillard L, Sabo N, Tod M, Labat L, Chasport C, Chevaleyre C, Thibaut F, Barré J, Azuar J, Questel F, Vorspan F, Bloch V, Bellivier F, Granger B, Barrault C, Declèves X. Population pharmacokinetics of oral baclofen at steady- state in alcoholic-dependent adult patients. Fundam Clin Pharmacol. 2018 Apr;32(2):239-248. doi: 10.1111/fcp.12330. Epub 2017 Nov 23. PMID: 29091319.

Goury A, Poirson F, Chaput U, Voicu S, Garçon P, Beeken T, Malissin I, Kerdjana L, Chelly J, Vodovar D, Oueslati H, Ekherian JM, Marteau P, Vicaut E, Megarbane B, Deye N. Targeted temperature management using the "Esophageal Cooling Device" after cardiac arrest (the COOL study): A feasibility and safety study. Resuscitation. 2017 Dec;121:54-61. doi: 10.1016/j.resuscitation.2017.09.021. Epub 2017 Sep 23. PMID: 28951293.

Picard L, Cherait C, Constant O, Boulanger B, Dorget A, Vodovar D, Fiore A, Haouache H, Dhonneur G, Mongardon N. Central venous catheter placement during extracorporeal membrane oxygenation therapy. Anaesth Crit Care Pain Med. 2018 Jun;37(3):269-270. doi: 10.1016/j.accpm.2017.05.005. Epub 2017 Jul 26. PMID: 28756332.

Robert R, Le Gouge A, Kentish-Barnes N, Cottereau A, Giraudeau B, Adda M, Annane D, Audibert J, Barbier F, Bardou P, Bourcier S, Bourenne J, Boyer A, Brenas F, Das V, Desachy A, Devaquet J, Feissel M, Ganster F, Garrouste-Orgeas M, Grillet G, Guisset O, Hamidfar-Roy R, Hyacinthe AC, Jochmans S, Jourdain M, Lautrette A, Lerolle N, Lesieur O, Lion F, Mateu P, Megarbane B, Merceron S, Mercier E, Messika J, Morin-Longuet P, Philippon-Jouve B, Quenot JP, Renault A, Repesse X, Rigaud JP, Robin S, Roquilly A, Seguin A, Thevenin D, Tirot P, Vinatier I, Azoulay E, Reignier J. Terminal weaning or immediate extubation for withdrawing mechanical ventilation in critically ill patients (the ARREVE observational study). Intensive Care Med. 2017 Dec;43(12):1793-1807. doi: 10.1007/s00134-017-4891-0. Epub 2017 Sep 22. Erratum in: Intensive Care Med. 2017 Nov 24;: PMID: 28936597.

Charlier C, Perrodeau É, Leclercq A, Cazenave B, Pilmis B, Henry B, Lopes A, Maury MM, Moura A, Goffinet F, Dieye HB, Thouvenot P, Ungeheuer MN, Tourdjman M, Goulet V, de Valk H, Lortholary O, Ravaud P, Lecuit M; MONALISA study group. Clinical features and prognostic factors of listeriosis: the MONALISA national prospective cohort study. Lancet Infect Dis. 2017 May;17(5):510-519. doi: 10.1016/S1473-3099(16)30521-7. Epub 2017 Jan 28. Erratum in: Lancet Infect Dis. 2017 Sep;17(9):897. PMID: 28139432.

Labat L, Goncalves A, Marques AR, Duretz B, Granger B, Declèves X. Liquid chromatography high resolution mass spectrometry for the determination o baclofen and its metabolites in plasma: Application to therapeutic drug monitoring. Biomed Chromatogr. 2017 Aug;31(8). doi: 10.1002/bmc.3936. Epub 2017 Feb 17. PMID: 28087970.

Miró Ò, Galicia M, Dargan P, Dines AM, Giraudon I, Heyerdahl F, Hovda KE, Yates C, Wood DM, Liakoni E, Liechti M, Jürgens G, Pedersen CB, O'Connor N, Markey G, Moughty A, Lee C, O'Donohoe P, Sein Anand J, Puiguriguer J, Homar C, Eyer F, Vallersnes OM, Persett PS, Chevillard L, Mégarbane B, Paasma R, Waring WS, Põld K, Rabe C, Kabata PM. Intoxication by gamma hydroxybutyrate and related analogues: Clinical characteristics and comparison between pure intoxication and that combined with other substances of abuse. Toxicol Lett. 2017 Aug 5;277:84-91. doi: 10.1016/j.toxlet.2017.05.030. Epub 2017 Jun 1. PMID: 28579487.

Stout J, Hanak AS, Chevillard L, Djemaï B, Risède P, Giacomini E, Poupon J, Barrière DA, Bellivier F, Mégarbane B, Boumezbeur F. Investigation of lithium distribution in the rat brain ex vivo using lithium-7 magnetic resonance spectroscopy and imaging at 17.2 T. NMR Biomed. 2017 Nov;30(11). doi: 10.1002/nbm.3770. Epub 2017 Jul 13. PMID: 28703506.

Barbara G, Mégarbane B, Argaud L, Louis G, Lerolle N, Schneider F, Gaudry S, Barbarot N, Jamet A, Outin H, Gibot S, Bollaert PE. Functional outcome of patients with prolonged hypoglycemic encephalopathy. Ann Intensive Care. 2017 Dec;7(1):54. doi: 10.1186/s13613-017-0277-2. Epub 2017 May 22. PMID: 28534234; PMCID: PMC5440422.

Cerland L, Mégarbane B, Kallel H, Brouste Y, Mehdaoui H, Resiere D. Incidence and Consequences of Near-Drowning-Related Pneumonia-A Descriptive Series from Martinique, French West Indies. Int J Environ Res Public Health. 2017 Nov 17;14(11):1402. doi: 10.3390/ijerph14111402. PMID: 29149019; PMCID: PMC5708041.

Lagard C, Malissin I, Indja W, Risède P, Chevillard L, Mégarbane B. Is naloxone the best antidote to reverse tramadol-induced neuro-respiratory toxicity in overdose? An experimental investigation in the rat. Clin Toxicol (Phila). 2018 Aug;56(8):737-743. doi: 10.1080/15563650.2017.1401080. Epub 2017 Nov 17. PMID: 29148295.

Gaudry S, Sztrymf B, Sonneville R, Megarbane B, Van Der Meersch G, Vodovar D, Cohen Y, Ricard JD, Hajage D, Salomon L, Dreyfuss D. Loxapine to control agitation during weaning from mechanical ventilation. Crit Care. 2017 Sep 6;21(1):235. doi: 10.1186/s13054-017-1822-y. PMID: 28877705; PMCID: PMC5586048.

Vodovar D, Mégarbane B. Prognosis and outcome of severe lithium poisoning. J Psychopharmacol. 2017 Sep;31(9):1274-1277. doi: 10.1177/0269881117699168. PMID: 28918709.

Hanak AS, Chevillard L, Lebeau R, Risède P, Laplanche JL, Benturquia N, Mégarbane B. Neurobehavioral effects of lithium in the rat: Investigation of the effect/concentration relationships and the contribution of the poisoning pattern. Prog Neuropsychopharmacol Biol Psychiatry. 2017 Jun 2;76:124-133. doi: 10.1016/j.pnpbp.2017.03.005. Epub 2017 Mar 20. PMID: 28336491.

Nisse C, Tagne-Fotso R, Howsam M; Members of Health Examination Centres of the Nord − Pas-de-Calais region network; Richeval C, Labat L, Leroyer A. Blood and urinary levels of metals and metalloids in the general adult population of Northern France: The IMEPOGE study, 2008-2010. Int J Hyg Environ Health. 2017 Apr;220(2 Pt B):341-363. doi: 10.1016/j.ijheh.2016.09.020. Epub 2016 Oct 3. PMID: 27931767.

Hachon L, Reis R, Labat L, Poitou C, Jacob A, Declèves X, Lloret-Linares C. Morphine and metabolites plasma levels after administration of sustained release morphine in Roux-en-Y gastric bypass subjects versus matched control subjects. Surg Obes Relat Dis. 2017 Nov;13(11):1869-1874. doi: 10.1016/j.soard.2017.07.030. Epub 2017 Aug 3. PMID: 8864105.

Lagard C, Chevillard L, Guillemyn K, Risède P, Laplanche JL, Spetea M, Ballet S, Mégarbane B. Bifunctional peptide-based opioid agonist/nociception antagonist ligand for dual treatment of nociceptive and neuropathic pain. Pain. 2017 Mar;158(3):505-515. doi: 10.1097/j.pain.0000000000000790. PMID: 28135212; PMCID: PMC5302413.

Vodovar D, Mégarbane B. Do not Forget Gastrointestinal Decontamination in the Early Management of Lithium Poisoning. Basic Clin Pharmacol Toxicol. 2017 May;120(5):415-416. doi: 10.1111/bcpt.12758. Epub 2017 Mar 10. PMID: 28296278.

Taib T, Leconte C, Van Steenwinckel J, Cho AH, Palmier P, Torsello E, Lai Kuen R, Onyeomah S, Ecomard K, Benedetto C, Coqueran B, Novak A-C, Deou E, Plotkine M, Gressens P, Marchand-Leroux C, Besson VC. Neuroinflammation, myelin and behavior : temporal patterns following mild traumatic brain injury in mice. PLosOne. 2017 Sept;12 (9): e0184811. PMID: 28910378; PMCID: PMC5599047

Charriaut-Marlangue C, Besson VC, Baud O. Sexually dimorphic outcomes after neonatal stroke and hypoxia-ischemia. Int J Mol Sci. 2017 Dec;19 (1): 61. PMID: 29278365; PMCID: PMC5796011.

Cohier C, Mégarbane B, Roussel O. Illicit Drugs in Oral Fluid: Evaluation of Two Collection Devices. J Anal Toxicol. 2017 Jan;41(1):71-76. doi: 10.1093/jat/bkw100. Epub 2016 Sep 27. PMID: 27681339.

Hanak AS, Malissin I, Poupon J, Risède P, Chevillard L, Mégarbane B. Electroencephalographic patterns of lithium poisoning: a study of the effect/concentration relationships in the rat. Bipolar Disord. 2017 Mar;19(2):135-145. doi: 10.1111/bdi.12482. Epub 2017 Apr 20. PMID: 28425670.

Asfar P, Schortgen F, Boisramé-Helms J, Charpentier J, Guérot E, Megarbane B, Grimaldi D, Grelon F, Anguel N, Lasocki S, Henry-Lagarrigue M, Gonzalez F, Legay F, Guitton C, Schenck M, Doise JM, Devaquet J, Van Der Linden T, Chatellier D, Rigaud JP, Dellamonica J, Tamion F, Meziani F, Mercat A, Dreyfuss D, Seegers V, Radermacher P; HYPER2S Investigators; REVA research network. Hyperoxia and hypertonic saline in patients with septic shock (HYPERS2S): a two- by-two factorial, multicentre, randomised, clinical trial. Lancet Respir Med. 2017 Mar;5(3):180-190. doi: 10.1016/S2213-2600(17)30046-2. Epub 2017 Feb 15. Erratum in: Lancet Respir Med. 2017 Aug;5(8):e28. PMID: 28219612.

St-Onge M, Anseeuw K, Cantrell FL, Gilchrist IC, Hantson P, Bailey B, Lavergne V, Gosselin S, Kerns W 2nd, Laliberté M, Lavonas EJ, Juurlink DN, Muscedere J, Yang CC, Sinuff T, Rieder M, Mégarbane B. Experts Consensus Recommendations for the Management of Calcium Channel Blocker Poisoning in Adults. Crit Care Med. 2017 Mar;45(3):e306-e315. doi: 10.1097/CCM.0000000000002087. PMID: 27749343; PMCID: PMC5312725.

Cohier C, Chevillard L, Salle S, Risède P, Roussel O, Mégarbane B. Editor's Highlight: Neurorespiratory Effects of Buprenorphine and Ethanol in Combination: A Mechanistic Study of Drug-Drug Interactions in the Rat. Toxicol Sci. 2017 Feb;155(2):389-399. doi: 10.1093/toxsci/kfw221. PMID: 27803387.

Montravers P et al. AmarCAND2 Study Group. Antifungal therapy for patients with proven or suspected Candida peritonitis: Amarcand2, a prospective cohort study in French intensive care units. Clin Microbiol Infect. 2017 Feb;23(2):117.e1-117.e8. doi: 10.1016/j.cmi.2016.10.001. PMID: 27746395.

Vodovar D, Mégarbane B. Defining predictive factors of severity and indications for extracorporeal toxin removal in lithium poisoning: not an easy objective! Clin Toxicol (Phila). 2017 Jan;55(1):69-70. doi: 10.1080/15563650.2016.1244339. PMID: 27758145.

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